# Unsupervised Domain Adaptive Fundus Image Segmentation with Category-level Regularization

arXiv: https://arxiv.org/abs/2207.03684 · HTML: https://mlsanity.com/paper/2207.03684/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 24 references that are in the map.
- First posted on arXiv 8 Jul 2022.

## Builds on (most cited first, 14 of 14)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [FixMatch: Simplifying Semi-Supervised Learning with Consistency and Confidence](https://mlsanity.com/paper/2001.07685/) (2020)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [FCNs in the Wild: Pixel-level Adversarial and Constraint-based Adaptation](https://mlsanity.com/paper/1612.02649/) (2016)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [Cross-domain Object Detection through Coarse-to-Fine Feature Adaptation](https://mlsanity.com/paper/2003.10275/) (2020)
- [Unsupervised Cross-Modality Domain Adaptation of ConvNets for Biomedical Image Segmentations with Adversarial Loss](https://mlsanity.com/paper/1804.10916/) (2018)
- [Source-Free Domain Adaptive Fundus Image Segmentation with Denoised Pseudo-Labeling](https://mlsanity.com/paper/2109.09735/) (2021)
- [Task Driven Generative Modeling for Unsupervised Domain Adaptation: Application to X-ray Image Segmentation](https://mlsanity.com/paper/1806.07201/) (2018)
- [Boundary and Entropy-driven Adversarial Learning for Fundus Image Segmentation](https://mlsanity.com/paper/1906.11143/) (2019)
- [Patch-based Output Space Adversarial Learning for Joint Optic Disc and Cup Segmentation](https://mlsanity.com/paper/1902.07519/) (2019)
- [Improving Medical Image Classification with Label Noise Using Dual-uncertainty Estimation](https://mlsanity.com/paper/2103.00528/) (2021)

## Built on by (most cited first, 6 of 6)

- [Deep learning for unsupervised domain adaptation in medical imaging: Recent advancements and future perspectives](https://mlsanity.com/paper/2308.01265/) (2023)
- [Generalized Category Discovery under Domain Shift: A Frequency Domain Perspective](https://mlsanity.com/paper/2511.00573/) (2025)
- [Unsupervised Domain Adaptive Fundus Image Segmentation with Few Labeled Source Data](https://mlsanity.com/paper/2210.04379/) (2022)
- [Grad-CL: Source Free Domain Adaptation with Gradient Guided Feature Disalignment](https://mlsanity.com/paper/2509.10134/) (2025)
- [Distribution Aligned Diffusion and Prototype-guided network for Unsupervised Domain Adaptive Segmentation](https://mlsanity.com/paper/2303.12313/) (2023)
- [Nested Radially Monotone Polar Occupancy Estimation: Clinically-Grounded Optic Disc and Cup Segmentation for Glaucoma Screening](https://mlsanity.com/paper/2604.09062/) (2026)

## Abstract (arXiv)

Existing unsupervised domain adaptation methods based on adversarial learning have achieved good performance in several medical imaging tasks. However, these methods focus only on global distribution adaptation and ignore distribution constraints at the category level, which would lead to sub-optimal adaptation performance. This paper presents an unsupervised domain adaptation framework based on category-level regularization that regularizes the category distribution from three perspectives. Specifically, for inter-domain category regularization, an adaptive prototype alignment module is proposed to align feature prototypes of the same category in the source and target domains. In addition, for intra-domain category regularization, we tailored a regularization technique for the source and target domains, respectively. In the source domain, a prototype-guided discriminative loss is proposed to learn more discriminative feature representations by enforcing intra-class compactness and inter-class separability, and as a complement to traditional supervised loss. In the target domain, an augmented consistency category regularization loss is proposed to force the model to produce consistent predictions for augmented/unaugmented target images, which encourages semantically similar regions to be given the same label. Extensive experiments on two publicly fundus datasets show that the proposed approach significantly outperforms other state-of-the-art comparison algorithms.