# Histopathology DatasetGAN: Synthesizing Large-Resolution Histopathology Datasets

arXiv: https://arxiv.org/abs/2207.02712 · HTML: https://mlsanity.com/paper/2207.02712/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 17 references that are in the map.
- First posted on arXiv 6 Jul 2022.

## Builds on (most cited first, 13 of 13)

- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [FixMatch: Simplifying Semi-Supervised Learning with Consistency and Confidence](https://mlsanity.com/paper/2001.07685/) (2020)
- [MixMatch: A Holistic Approach to Semi-Supervised Learning](https://mlsanity.com/paper/1905.02249/) (2019)
- [Training Generative Adversarial Networks with Limited Data](https://mlsanity.com/paper/2006.06676/) (2020)
- [Mean teachers are better role models: Weight-averaged consistency targets improve semi-supervised deep learning results](https://mlsanity.com/paper/1703.01780/) (2017)
- [DatasetGAN: Efficient Labeled Data Factory with Minimal Human Effort](https://mlsanity.com/paper/2104.06490/) (2021)
- [Medical Image Segmentation Using Deep Learning: A Survey](https://mlsanity.com/paper/2009.13120/) (2020)
- [Semantic Segmentation with Generative Models: Semi-Supervised Learning and Strong Out-of-Domain Generalization](https://mlsanity.com/paper/2104.05833/) (2021)
- [Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/1903.00348/) (2019)
- [BigDatasetGAN: Synthesizing ImageNet with Pixel-wise Annotations](https://mlsanity.com/paper/2201.04684/) (2022)
- [Few-shot 3D Multi-modal Medical Image Segmentation using Generative Adversarial Learning](https://mlsanity.com/paper/1810.12241/) (2018)
- [Learning High-Resolution Domain-Specific Representations with a GAN Generator](https://mlsanity.com/paper/2006.10451/) (2020)
- [Application of DatasetGAN in medical imaging: preliminary studies](https://mlsanity.com/paper/2202.13463/) (2022)

## Abstract (arXiv)

Self-supervised learning (SSL) methods are enabling an increasing number of deep learning models to be trained on image datasets in domains where labels are difficult to obtain. These methods, however, struggle to scale to the high resolution of medical imaging datasets, where they are critical for achieving good generalization on label-scarce medical image datasets. In this work, we propose the Histopathology DatasetGAN (HDGAN) framework, an extension of the DatasetGAN semi-supervised framework for image generation and segmentation that scales well to large-resolution histopathology images. We make several adaptations from the original framework, including updating the generative backbone, selectively extracting latent features from the generator, and switching to memory-mapped arrays. These changes reduce the memory consumption of the framework, improving its applicability to medical imaging domains. We evaluate HDGAN on a thrombotic microangiopathy high-resolution tile dataset, demonstrating strong performance on the high-resolution image-annotation generation task. We hope that this work enables more application of deep learning models to medical datasets, in addition to encouraging more exploration of self-supervised frameworks within the medical imaging domain.