# DU-Net based Unsupervised Contrastive Learning for Cancer Segmentation in Histology Images

arXiv: https://arxiv.org/abs/2206.08791 · HTML: https://mlsanity.com/paper/2206.08791/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 20 references that are in the map.
- First posted on arXiv 17 Jun 2022.

## Builds on (most cited first, 15 of 15)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Improved Baselines with Momentum Contrastive Learning](https://mlsanity.com/paper/2003.04297/) (2020)
- [Improved Regularization of Convolutional Neural Networks with Cutout](https://mlsanity.com/paper/1708.04552/) (2017)
- [Unsupervised Representation Learning by Predicting Image Rotations](https://mlsanity.com/paper/1803.07728/) (2018)
- [Unsupervised Learning of Visual Representations by Solving Jigsaw Puzzles](https://mlsanity.com/paper/1603.09246/) (2016)
- [Colorful Image Colorization](https://mlsanity.com/paper/1603.08511/) (2016)
- [Unsupervised Visual Representation Learning by Context Prediction](https://mlsanity.com/paper/1505.05192/) (2015)
- [Learning Representations by Maximizing Mutual Information Across Views](https://mlsanity.com/paper/1906.00910/) (2019)
- [Contrastive learning of global and local features for medical image segmentation with limited annotations](https://mlsanity.com/paper/2006.10511/) (2020)
- [Discriminative Unsupervised Feature Learning with Exemplar Convolutional Neural Networks](https://mlsanity.com/paper/1406.6909/) (2014)
- [Contrastive Learning based Hybrid Networks for Long-Tailed Image Classification](https://mlsanity.com/paper/2103.14267/) (2021)
- [Some Improvements on Deep Convolutional Neural Network Based Image Classification](https://mlsanity.com/paper/1312.5402/) (2013)

## Built on by (most cited first, 1 of 1)

- [TUMLS: Trustful Fully Unsupervised Multi-Level Segmentation for Whole Slide Images of Histology](https://mlsanity.com/paper/2504.12718/) (2025)

## Abstract (arXiv)

In this paper, we introduce an unsupervised cancer segmentation framework for histology images. The framework involves an effective contrastive learning scheme for extracting distinctive visual representations for segmentation. The encoder is a Deep U-Net (DU-Net) structure that contains an extra fully convolution layer compared to the normal U-Net. A contrastive learning scheme is developed to solve the problem of lacking training sets with high-quality annotations on tumour boundaries. A specific set of data augmentation techniques are employed to improve the discriminability of the learned colour features from contrastive learning. Smoothing and noise elimination are conducted using convolutional Conditional Random Fields. The experiments demonstrate competitive performance in segmentation even better than some popular supervised networks.