# U-PET: MRI-based Dementia Detection with Joint Generation of Synthetic FDG-PET Images

arXiv: https://arxiv.org/abs/2206.08078 · HTML: https://mlsanity.com/paper/2206.08078/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 29 references that are in the map.
- First posted on arXiv 16 Jun 2022.

## Builds on (most cited first, 13 of 13)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Deeply-Supervised Nets](https://mlsanity.com/paper/1409.5185/) (2014)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)
- [Convolutional Neural Networks for Classification of Alzheimer's Disease: Overview and Reproducible Evaluation](https://mlsanity.com/paper/1904.07773/) (2019)
- [Attention-Gated Networks for Improving Ultrasound Scan Plane Detection](https://mlsanity.com/paper/1804.05338/) (2018)
- [DUAL-GLOW: Conditional Flow-Based Generative Model for Modality Transfer](https://mlsanity.com/paper/1908.08074/) (2019)
- [Reproducible evaluation of classification methods in Alzheimer's disease: framework and application to MRI and PET data](https://mlsanity.com/paper/1808.06452/) (2018)
- [MRI to FDG-PET: Cross-Modal Synthesis Using 3D U-Net For Multi-Modal Alzheimer's Classification](https://mlsanity.com/paper/1807.10111/) (2018)

## Built on by (most cited first, 1 of 1)

- [Predicting Hypoxia in Brain Tumors from Multiparametric MRI](https://mlsanity.com/paper/2401.14171/) (2024)

## Abstract (arXiv)

Alzheimer's disease (AD) is the most common cause of dementia. An early detection is crucial for slowing down the disease and mitigating risks related to the progression. While the combination of MRI and FDG-PET is the best image-based tool for diagnosis, FDG-PET is not always available. The reliable detection of Alzheimer's disease with only MRI could be beneficial, especially in regions where FDG-PET might not be affordable for all patients. To this end, we propose a multi-task method based on U-Net that takes T1-weighted MR images as an input to generate synthetic FDG-PET images and classifies the dementia progression of the patient into cognitive normal (CN), cognitive impairment (MCI), and AD. The attention gates used in both task heads can visualize the most relevant parts of the brain, guiding the examiner and adding interpretability. Results show the successful generation of synthetic FDG-PET images and a performance increase in disease classification over the naive single-task baseline.