# BInGo: Bayesian Intrinsic Groupwise Registration via Explicit Hierarchical Disentanglement

arXiv: https://arxiv.org/abs/2206.02377 · HTML: https://mlsanity.com/paper/2206.02377/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 19 of its 37 references that are in the map.
- First posted on arXiv 6 Jun 2022.

## Builds on (most cited first, 19 of 19)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Group Equivariant Convolutional Networks](https://mlsanity.com/paper/1602.07576/) (2016)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [NVAE: A Deep Hierarchical Variational Autoencoder](https://mlsanity.com/paper/2007.03898/) (2020)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [Domain-Specific Batch Normalization for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1906.03950/) (2019)
- [Unsupervised Learning of Probabilistic Diffeomorphic Registration for Images and Surfaces](https://mlsanity.com/paper/1903.03545/) (2019)
- [Variational Mixture-of-Experts Autoencoders for Multi-Modal Deep Generative Models](https://mlsanity.com/paper/1911.03393/) (2019)
- [A Deep Learning Framework for Unsupervised Affine and Deformable Image Registration](https://mlsanity.com/paper/1809.06130/) (2018)
- [Multivariate mixture model for myocardium segmentation combining multi-source images](https://mlsanity.com/paper/1612.08820/) (2016)
- [Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learning](https://mlsanity.com/paper/2112.04489/) (2021)
- [Weakly-Supervised Convolutional Neural Networks for Multimodal Image Registration](https://mlsanity.com/paper/1807.03361/) (2018)
- [Deforming Autoencoders: Unsupervised Disentangling of Shape and Appearance](https://mlsanity.com/paper/1806.06503/) (2018)
- [Unsupervised Deformable Registration for Multi-Modal Images via Disentangled Representations](https://mlsanity.com/paper/1903.09331/) (2019)
- [Cardiac Segmentation on Late Gadolinium Enhancement MRI: A Benchmark Study from Multi-Sequence Cardiac MR Segmentation Challenge](https://mlsanity.com/paper/2006.12434/) (2020)
- [Explicit Disentanglement of Appearance and Perspective in Generative Models](https://mlsanity.com/paper/1906.11881/) (2019)
- [Deformable Generator Networks: Unsupervised Disentanglement of Appearance and Geometry](https://mlsanity.com/paper/1806.06298/) (2018)
- [MvMM-RegNet: A new image registration framework based on multivariate mixture model and neural network estimation](https://mlsanity.com/paper/2006.15573/) (2020)

## Built on by (most cited first, 3 of 3)

- [Bayesian Unsupervised Disentanglement of Anatomy and Geometry for Deep Groupwise Image Registration](https://mlsanity.com/paper/2401.02141/) (2024)
- [Unified and Semantically Grounded Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/2508.08660/) (2025)
- [GrInAdapt: Scaling Retinal Vessel Structural Map Segmentation Through Grounding, Integrating and Adapting Multi-device, Multi-site, and Multi-modal Fundus Domains](https://mlsanity.com/paper/2503.05991/) (2025)

## Abstract (arXiv)

Multimodal groupwise registration aligns internal structures in a group of medical images. Current approaches to this problem involve developing similarity measures over the joint intensity profile of all images, which may be computationally prohibitive for large image groups and unstable under various conditions. To tackle these issues, we propose BInGo, a general unsupervised hierarchical Bayesian framework based on deep learning, to learn intrinsic structural representations to measure the similarity of multimodal images. Particularly, a variational auto-encoder with a novel posterior is proposed, which facilitates the disentanglement learning of structural representations and spatial transformations, and characterizes the imaging process from the common structure with shape transition and appearance variation. Notably, BInGo is scalable to learn from small groups, whereas being tested for large-scale groupwise registration, thus significantly reducing computational costs. We compared BInGo with five iterative or deep learning methods on three public intrasubject and intersubject datasets, i.e. BraTS, MS-CMR of the heart, and Learn2Reg abdomen MR-CT, and demonstrated its superior accuracy and computational efficiency, even for very large group sizes (e.g., over 1300 2D images from MS-CMR in each group).