# Robust Medical Image Classification from Noisy Labeled Data with Global and Local Representation Guided Co-training

arXiv: https://arxiv.org/abs/2205.04723 · HTML: https://mlsanity.com/paper/2205.04723/

## Key facts

- Cited by 21 papers in the map (data through 14 Oct 2026).
- Builds on 32 of its 53 references that are in the map.
- First posted on arXiv 10 May 2022.

## Builds on (most cited first, 30 of 32)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Understanding deep learning requires rethinking generalization](https://mlsanity.com/paper/1611.03530/) (2016)
- [MixMatch: A Holistic Approach to Semi-Supervised Learning](https://mlsanity.com/paper/1905.02249/) (2019)
- [Co-teaching: Robust Training of Deep Neural Networks with Extremely Noisy Labels](https://mlsanity.com/paper/1804.06872/) (2018)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [DivideMix: Learning with Noisy Labels as Semi-supervised Learning](https://mlsanity.com/paper/2002.07394/) (2020)
- [Learning to Reweight Examples for Robust Deep Learning](https://mlsanity.com/paper/1803.09050/) (2018)
- [Making Deep Neural Networks Robust to Label Noise: a Loss Correction Approach](https://mlsanity.com/paper/1609.03683/) (2016)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [Rotation Equivariant CNNs for Digital Pathology](https://mlsanity.com/paper/1806.03962/) (2018)
- [Early-Learning Regularization Prevents Memorization of Noisy Labels](https://mlsanity.com/paper/2007.00151/) (2020)
- [Joint Optimization Framework for Learning with Noisy Labels](https://mlsanity.com/paper/1803.11364/) (2018)
- [Decoupling "when to update" from "how to update"](https://mlsanity.com/paper/1706.02613/) (2017)
- [Using Trusted Data to Train Deep Networks on Labels Corrupted by Severe Noise](https://mlsanity.com/paper/1802.05300/) (2018)
- [Understanding and Utilizing Deep Neural Networks Trained with Noisy Labels](https://mlsanity.com/paper/1905.05040/) (2019)
- [Are Anchor Points Really Indispensable in Label-Noise Learning?](https://mlsanity.com/paper/1906.00189/) (2019)
- [Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge](https://mlsanity.com/paper/1612.08012/) (2016)
- [Deep learning with noisy labels: exploring techniques and remedies in medical image analysis](https://mlsanity.com/paper/1912.02911/) (2019)
- [SELF: Learning to Filter Noisy Labels with Self-Ensembling](https://mlsanity.com/paper/1910.01842/) (2019)
- [Dual T: Reducing Estimation Error for Transition Matrix in Label-noise Learning](https://mlsanity.com/paper/2006.07805/) (2020)
- [Iterative Learning with Open-set Noisy Labels](https://mlsanity.com/paper/1804.00092/) (2018)
- [Deep Learning for Identifying Metastatic Breast Cancer](https://mlsanity.com/paper/1606.05718/) (2016)
- [Error-Bounded Correction of Noisy Labels](https://mlsanity.com/paper/2011.10077/) (2020)
- [Detecting Cancer Metastases on Gigapixel Pathology Images](https://mlsanity.com/paper/1703.02442/) (2017)
- [Classification and Disease Localization in Histopathology Using Only Global Labels: A Weakly-Supervised Approach](https://mlsanity.com/paper/1802.02212/) (2018)
- [Robust Learning at Noisy Labeled Medical Images: Applied to Skin Lesion Classification](https://mlsanity.com/paper/1901.07759/) (2019)
- [A Semi-Supervised Two-Stage Approach to Learning from Noisy Labels](https://mlsanity.com/paper/1802.02679/) (2018)
- [A Two-Stream Mutual Attention Network for Semi-supervised Biomedical Segmentation with Noisy Labels](https://mlsanity.com/paper/1807.11719/) (2018)
- [Pick-and-Learn: Automatic Quality Evaluation for Noisy-Labeled Image Segmentation](https://mlsanity.com/paper/1907.11835/) (2019)
- [Hyperspectral Image Classification in the Presence of Noisy Labels](https://mlsanity.com/paper/1809.04212/) (2018)

## Built on by (most cited first, 21 of 21)

- [A Conformal Prediction Score that is Robust to Label Noise](https://mlsanity.com/paper/2405.02648/) (2024)
- [Backdoor Attack and Defense in Federated Generative Adversarial Network-based Medical Image Synthesis](https://mlsanity.com/paper/2210.10886/) (2022)
- [EndoOmni: Zero-Shot Cross-Dataset Depth Estimation in Endoscopy by Robust Self-Learning from Noisy Labels](https://mlsanity.com/paper/2409.05442/) (2024)
- [Deep learning with noisy labels in medical prediction problems: a scoping review](https://mlsanity.com/paper/2403.13111/) (2024)
- [Improving Medical Image Classification in Noisy Labels Using Only Self-supervised Pretraining](https://mlsanity.com/paper/2308.04551/) (2023)
- [A Systematic Review of Generalization Research in Medical Image Classification](https://mlsanity.com/paper/2403.12167/) (2024)
- [Data efficient deep learning for medical image analysis: A survey](https://mlsanity.com/paper/2310.06557/) (2023)
- [Assessing and Enhancing Robustness of Deep Learning Models with Corruption Emulation in Digital Pathology](https://mlsanity.com/paper/2310.20427/) (2023)
- [Towards Few-Shot Learning in the Open World: A Review and Beyond](https://mlsanity.com/paper/2408.09722/) (2024)
- [Conformal Prediction of Classifiers with Many Classes based on Noisy Labels](https://mlsanity.com/paper/2501.12749/) (2025)
- [Improving Robustness and Reliability in Medical Image Classification with Latent-Guided Diffusion and Nested-Ensembles](https://mlsanity.com/paper/2310.15952/) (2023)
- [Light-weight Fine-tuning Method for Defending Adversarial Noise in Pre-trained Medical Vision-Language Models](https://mlsanity.com/paper/2407.02716/) (2024)
- [DIOR-ViT: Differential Ordinal Learning Vision Transformer for Cancer Classification in Pathology Images](https://mlsanity.com/paper/2407.08503/) (2024)
- [Active Label Refinement for Robust Training of Imbalanced Medical Image Classification Tasks in the Presence of High Label Noise](https://mlsanity.com/paper/2407.05973/) (2024)
- [Curriculum Fine-tuning of Vision Foundation Model for Medical Image Classification Under Label Noise](https://mlsanity.com/paper/2412.00150/) (2024)
- [How does self-supervised pretraining improve robustness against noisy labels across various medical image classification datasets?](https://mlsanity.com/paper/2401.07990/) (2024)
- [Unleashing the Potential of Open-set Noisy Samples Against Label Noise for Medical Image Classification](https://mlsanity.com/paper/2406.12293/) (2024)
- [Label Filling via Mixed Supervision for Medical Image Segmentation from Noisy Annotations](https://mlsanity.com/paper/2410.16057/) (2024)
- [Asymmetric Co-Training with Explainable Cell Graph Ensembling for Histopathological Image Classification](https://mlsanity.com/paper/2308.12737/) (2023)
- [Sample selection with noise rate estimation in noise learning of medical image analysis](https://mlsanity.com/paper/2312.15233/) (2023)
- [Noise-aware few-shot learning through bi-directional multi-view prompt alignment](https://mlsanity.com/paper/2603.11617/) (2026)

## Abstract (arXiv)

Deep neural networks have achieved remarkable success in a wide variety of natural image and medical image computing tasks. However, these achievements indispensably rely on accurately annotated training data. If encountering some noisy-labeled images, the network training procedure would suffer from difficulties, leading to a sub-optimal classifier. This problem is even more severe in the medical image analysis field, as the annotation quality of medical images heavily relies on the expertise and experience of annotators. In this paper, we propose a novel collaborative training paradigm with global and local representation learning for robust medical image classification from noisy-labeled data to combat the lack of high quality annotated medical data. Specifically, we employ the self-ensemble model with a noisy label filter to efficiently select the clean and noisy samples. Then, the clean samples are trained by a collaborative training strategy to eliminate the disturbance from imperfect labeled samples. Notably, we further design a novel global and local representation learning scheme to implicitly regularize the networks to utilize noisy samples in a self-supervised manner. We evaluated our proposed robust learning strategy on four public medical image classification datasets with three types of label noise,ie,random noise, computer-generated label noise, and inter-observer variability noise. Our method outperforms other learning from noisy label methods and we also conducted extensive experiments to analyze each component of our method.