# Anatomy-aware Self-supervised Learning for Anomaly Detection in Chest Radiographs

arXiv: https://arxiv.org/abs/2205.04282 · HTML: https://mlsanity.com/paper/2205.04282/

## Key facts

- Cited by 12 papers in the map (data through 14 Oct 2026).
- Builds on 33 of its 73 references that are in the map.
- First posted on arXiv 9 May 2022.

## Builds on (most cited first, 30 of 33)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Unsupervised Representation Learning by Predicting Image Rotations](https://mlsanity.com/paper/1803.07728/) (2018)
- [Context Encoders: Feature Learning by Inpainting](https://mlsanity.com/paper/1604.07379/) (2016)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [Unsupervised Learning of Visual Representations by Solving Jigsaw Puzzles](https://mlsanity.com/paper/1603.09246/) (2016)
- [Contrastive Learning of Medical Visual Representations from Paired Images and Text](https://mlsanity.com/paper/2010.00747/) (2020)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [CutPaste: Self-Supervised Learning for Anomaly Detection and Localization](https://mlsanity.com/paper/2104.04015/) (2021)
- [Likelihood Ratios for Out-of-Distribution Detection](https://mlsanity.com/paper/1906.02845/) (2019)
- [GANomaly: Semi-Supervised Anomaly Detection via Adversarial Training](https://mlsanity.com/paper/1805.06725/) (2018)
- [Big Self-Supervised Models Advance Medical Image Classification](https://mlsanity.com/paper/2101.05224/) (2021)
- [Deep Learning for Anomaly Detection: A Review](https://mlsanity.com/paper/2007.02500/) (2020)
- [Autoencoders for Unsupervised Anomaly Segmentation in Brain MR Images: A Comparative Study](https://mlsanity.com/paper/2004.03271/) (2020)
- [Self-Path: Self-supervision for Classification of Pathology Images with Limited Annotations](https://mlsanity.com/paper/2008.05571/) (2020)
- [SimCVD: Simple Contrastive Voxel-Wise Representation Distillation for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2108.06227/) (2021)
- [Generalized Radiograph Representation Learning via Cross-supervision between Images and Free-text Radiology Reports](https://mlsanity.com/paper/2111.03452/) (2021)
- [Deep One-Class Classification via Interpolated Gaussian Descriptor](https://mlsanity.com/paper/2101.10043/) (2021)
- [MoCo-CXR: MoCo Pretraining Improves Representation and Transferability of Chest X-ray Models](https://mlsanity.com/paper/2010.05352/) (2020)
- [Preservational Learning Improves Self-supervised Medical Image Models by Reconstructing Diverse Contexts](https://mlsanity.com/paper/2109.04379/) (2021)
- [MedAug: Contrastive learning leveraging patient metadata improves representations for chest X-ray interpretation](https://mlsanity.com/paper/2102.10663/) (2021)
- [Self-supervised Feature Learning via Exploiting Multi-modal Data for Retinal Disease Diagnosis](https://mlsanity.com/paper/2007.11067/) (2020)
- [How much data is needed to train a medical image deep learning system to achieve necessary high accuracy?](https://mlsanity.com/paper/1511.06348/) (2015)
- [Constrained Contrastive Distribution Learning for Unsupervised Anomaly Detection and Localisation in Medical Images](https://mlsanity.com/paper/2103.03423/) (2021)
- [COVID-19 Prognosis via Self-Supervised Representation Learning and Multi-Image Prediction](https://mlsanity.com/paper/2101.04909/) (2021)

## Built on by (most cited first, 12 of 12)

- [Robust and Efficient Medical Imaging with Self-Supervision](https://mlsanity.com/paper/2205.09723/) (2022)
- [MedIAnomaly: A comparative study of anomaly detection in medical images](https://mlsanity.com/paper/2404.04518/) (2024)
- [Exploiting Structural Consistency of Chest Anatomy for Unsupervised Anomaly Detection in Radiography Images](https://mlsanity.com/paper/2403.08689/) (2024)
- [AMAE: Adaptation of Pre-Trained Masked Autoencoder for Dual-Distribution Anomaly Detection in Chest X-Rays](https://mlsanity.com/paper/2307.12721/) (2023)
- [Position-Guided Prompt Learning for Anomaly Detection in Chest X-Rays](https://mlsanity.com/paper/2405.11976/) (2024)
- [AFiRe: Anatomy-Driven Self-Supervised Learning for Fine-Grained Representation in Radiographic Images](https://mlsanity.com/paper/2504.10972/) (2025)
- [DINO-LG: Enhancing Vision Transformers with Label Guidance for Coronary Artery Calcium Detection](https://mlsanity.com/paper/2411.07976/) (2024)
- [ART-ASyn: Anatomy-aware Realistic Texture-based Anomaly Synthesis Framework for Chest X-Rays](https://mlsanity.com/paper/2512.00310/) (2025)
- [Training Better Deep Learning Models Using Human Saliency](https://mlsanity.com/paper/2410.16190/) (2024)
- [DiSSECT: Structuring Transfer-Ready Medical Image Representations through Discrete Self-Supervision](https://mlsanity.com/paper/2509.18765/) (2025)
- [Towards Modality-Agnostic Medical Image Anomaly Detection: A Training-Free Manifold Refinement Approach](https://mlsanity.com/paper/2604.19191/) (2026)
- [AUCp: Pseudo-AUC for Inference Model Selection with Unlabeled Validation Data in Abnormality Detection](https://mlsanity.com/paper/2606.08742/) (2026)

## Abstract (arXiv)

Large numbers of labeled medical images are essential for the accurate detection of anomalies, but manual annotation is labor-intensive and time-consuming. Self-supervised learning (SSL) is a training method to learn data-specific features without manual annotation. Several SSL-based models have been employed in medical image anomaly detection. These SSL methods effectively learn representations in several field-specific images, such as natural and industrial product images. However, owing to the requirement of medical expertise, typical SSL-based models are inefficient in medical image anomaly detection. We present an SSL-based model that enables anatomical structure-based unsupervised anomaly detection (UAD). The model employs the anatomy-aware pasting (AnatPaste) augmentation tool. AnatPaste employs a threshold-based lung segmentation pretext task to create anomalies in normal chest radiographs, which are used for model pretraining. These anomalies are similar to real anomalies and help the model recognize them. We evaluate our model on three opensource chest radiograph datasets. Our model exhibit area under curves (AUC) of 92.1%, 78.7%, and 81.9%, which are the highest among existing UAD models. This is the first SSL model to employ anatomical information as a pretext task. AnatPaste can be applied in various deep learning models and downstream tasks. It can be employed for other modalities by fixing appropriate segmentation. Our code is publicly available at: https://github.com/jun-sato/AnatPaste.