# Target and Task specific Source-Free Domain Adaptive Image Segmentation

arXiv: https://arxiv.org/abs/2203.15792 · HTML: https://mlsanity.com/paper/2203.15792/

## Key facts

- Cited by 13 papers in the map (data through 14 Oct 2026).
- Builds on 20 of its 33 references that are in the map.
- First posted on arXiv 29 Mar 2022.

## Builds on (most cited first, 20 of 20)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Knowledge Distillation: A Survey](https://mlsanity.com/paper/2006.05525/) (2020)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [Learning to Adapt Structured Output Space for Semantic Segmentation](https://mlsanity.com/paper/1802.10349/) (2018)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [Medical Transformer: Gated Axial-Attention for Medical Image Segmentation](https://mlsanity.com/paper/2102.10662/) (2021)
- [Knowledge Distillation and Student-Teacher Learning for Visual Intelligence: A Review and New Outlooks](https://mlsanity.com/paper/2004.05937/) (2020)
- [Unsupervised domain adaptation for medical imaging segmentation with self-ensembling](https://mlsanity.com/paper/1811.06042/) (2018)
- [Source-Free Domain Adaptive Fundus Image Segmentation with Denoised Pseudo-Labeling](https://mlsanity.com/paper/2109.09735/) (2021)
- [Source-Relaxed Domain Adaptation for Image Segmentation](https://mlsanity.com/paper/2005.03697/) (2020)
- [Unsupervised Domain Adaptation via Disentangled Representations: Application to Cross-Modality Liver Segmentation](https://mlsanity.com/paper/1907.13590/) (2019)
- [KiU-Net: Towards Accurate Segmentation of Biomedical Images using Over-complete Representations](https://mlsanity.com/paper/2006.04878/) (2020)
- [Boundary and Entropy-driven Adversarial Learning for Fundus Image Segmentation](https://mlsanity.com/paper/1906.11143/) (2019)
- [Improving Robustness of Deep Learning Based Knee MRI Segmentation: Mixup and Adversarial Domain Adaptation](https://mlsanity.com/paper/1908.04126/) (2019)
- [Source-free unsupervised domain adaptation for cross-modality abdominal multi-organ segmentation](https://mlsanity.com/paper/2111.12221/) (2021)

## Built on by (most cited first, 13 of 13)

- [A Comprehensive Survey on Test-Time Adaptation under Distribution Shifts](https://mlsanity.com/paper/2303.15361/) (2023)
- [Source-Free Unsupervised Domain Adaptation: A Survey](https://mlsanity.com/paper/2301.00265/) (2022)
- [CLIP goes 3D: Leveraging Prompt Tuning for Language Grounded 3D Recognition](https://mlsanity.com/paper/2303.11313/) (2023)
- [Towards Online Domain Adaptive Object Detection](https://mlsanity.com/paper/2204.05289/) (2022)
- [SDC-UDA: Volumetric Unsupervised Domain Adaptation Framework for Slice-Direction Continuous Cross-Modality Medical Image Segmentation](https://mlsanity.com/paper/2305.11012/) (2023)
- [Navigating Distribution Shifts in Medical Image Analysis: A Survey](https://mlsanity.com/paper/2411.05824/) (2024)
- [Open-Set Automatic Target Recognition](https://mlsanity.com/paper/2211.05883/) (2022)
- [DDFP: Data-dependent Frequency Prompt for Source Free Domain Adaptation of Medical Image Segmentation](https://mlsanity.com/paper/2505.09927/) (2025)
- [Multi Task Consistency Guided Source-Free Test-Time Domain Adaptation Medical Image Segmentation](https://mlsanity.com/paper/2310.11766/) (2023)
- [Grad-CL: Source Free Domain Adaptation with Gradient Guided Feature Disalignment](https://mlsanity.com/paper/2509.10134/) (2025)
- [Local-Global Pseudo-label Correction for Source-free Domain Adaptive Medical Image Segmentation](https://mlsanity.com/paper/2308.14312/) (2023)
- [Robust Source-Free Domain Adaptation for Fundus Image Segmentation](https://mlsanity.com/paper/2310.16665/) (2023)
- [AdaptiveCDM: Source-Free Few-Shot Domain Adaptation for Cell Detection in Microscopic Images](https://mlsanity.com/paper/2503.03370/) (2025)

## Abstract (arXiv)

Solving the domain shift problem during inference is essential in medical imaging, as most deep-learning based solutions suffer from it. In practice, domain shifts are tackled by performing Unsupervised Domain Adaptation (UDA), where a model is adapted to an unlabelled target domain by leveraging the labelled source data. In medical scenarios, the data comes with huge privacy concerns making it difficult to apply standard UDA techniques. Hence, a closer clinical setting is Source-Free UDA (SFUDA), where we have access to source-trained model but not the source data during adaptation. Existing SFUDA methods rely on pseudo-label based self-training techniques to address the domain shift. However, these pseudo-labels often have high entropy due to domain shift and adapting the source model with noisy pseudo-labels leads to sub-optimal performance. To overcome this limitation, we propose a systematic two-stage approach for SFUDA comprising of target-specific adaptation followed by task-specific adaptation. In target-specific adaptation, we enhance the pseudo-label generation by minimizing high entropy regions using the proposed ensemble entropy minimization loss and a selective voting strategy. In task-specific adaptation, we exploit the enhanced pseudo-labels using a student-teacher framework to effectively learn segmentation on the target domain. We evaluate our proposed method on 2D fundus datasets and 3D MRI volumes across 7 different domain shifts where we perform better than existing UDA and SFUDA methods for medical image segmentation. Code is available at https://github.com/Vibashan/tt-sfuda.