# Slice Imputation: Intermediate Slice Interpolation for Anisotropic 3D Medical Image Segmentation

arXiv: https://arxiv.org/abs/2203.10773 · HTML: https://mlsanity.com/paper/2203.10773/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 34 of its 51 references that are in the map.
- First posted on arXiv 21 Mar 2022.

## Builds on (most cited first, 30 of 34)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [Enhanced Deep Residual Networks for Single Image Super-Resolution](https://mlsanity.com/paper/1707.02921/) (2017)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Image Super-Resolution Using Very Deep Residual Channel Attention Networks](https://mlsanity.com/paper/1807.02758/) (2018)
- [ESRGAN: Enhanced Super-Resolution Generative Adversarial Networks](https://mlsanity.com/paper/1809.00219/) (2018)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Accurate Image Super-Resolution Using Very Deep Convolutional Networks](https://mlsanity.com/paper/1511.04587/) (2015)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [A large annotated medical image dataset for the development and evaluation of segmentation algorithms](https://mlsanity.com/paper/1902.09063/) (2019)
- [Super SloMo: High Quality Estimation of Multiple Intermediate Frames for Video Interpolation](https://mlsanity.com/paper/1712.00080/) (2017)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)
- [Embracing Imperfect Datasets: A Review of Deep Learning Solutions for Medical Image Segmentation](https://mlsanity.com/paper/1908.10454/) (2019)
- [Video Frame Synthesis using Deep Voxel Flow](https://mlsanity.com/paper/1702.02463/) (2017)
- [View Synthesis by Appearance Flow](https://mlsanity.com/paper/1605.03557/) (2016)
- [Data augmentation using learned transformations for one-shot medical image segmentation](https://mlsanity.com/paper/1902.09383/) (2019)
- [Concurrent Spatial and Channel Squeeze & Excitation in Fully Convolutional Networks](https://mlsanity.com/paper/1803.02579/) (2018)
- [Synergistic Image and Feature Adaptation: Towards Cross-Modality Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/1901.08211/) (2019)
- [Beyond Sharing Weights for Deep Domain Adaptation](https://mlsanity.com/paper/1603.06432/) (2016)
- [3D Anisotropic Hybrid Network: Transferring Convolutional Features from 2D Images to 3D Anisotropic Volumes](https://mlsanity.com/paper/1711.08580/) (2017)
- [Cubic LSTMs for Video Prediction](https://mlsanity.com/paper/1904.09412/) (2019)
- [Bayesian Image Quality Transfer with CNNs: Exploring Uncertainty in dMRI Super-Resolution](https://mlsanity.com/paper/1705.00664/) (2017)
- [Dreaming More Data: Class-dependent Distributions over Diffeomorphisms for Learned Data Augmentation](https://mlsanity.com/paper/1510.02795/) (2015)
- [Learning Shape Priors for Robust Cardiac MR Segmentation from Multi-view Images](https://mlsanity.com/paper/1907.09983/) (2019)
- [Anatomy-specific classification of medical images using deep convolutional nets](https://mlsanity.com/paper/1504.04003/) (2015)

## Built on by (most cited first, 1 of 1)

- [VesselSDF: Distance Field Priors for Vascular Network Reconstruction](https://mlsanity.com/paper/2506.16556/) (2025)

## Abstract (arXiv)

We introduce a novel frame-interpolation-based method for slice imputation to improve segmentation accuracy for anisotropic 3D medical images, in which the number of slices and their corresponding segmentation labels can be increased between two consecutive slices in anisotropic 3D medical volumes. Unlike previous inter-slice imputation methods, which only focus on the smoothness in the axial direction, this study aims to improve the smoothness of the interpolated 3D medical volumes in all three directions: axial, sagittal, and coronal. The proposed multitask inter-slice imputation method, in particular, incorporates a smoothness loss function to evaluate the smoothness of the interpolated 3D medical volumes in the through-plane direction (sagittal and coronal). It not only improves the resolution of the interpolated 3D medical volumes in the through-plane direction but also transforms them into isotropic representations, which leads to better segmentation performances. Experiments on whole tumor segmentation in the brain, liver tumor segmentation, and prostate segmentation indicate that our method outperforms the competing slice imputation methods on both computed tomography and magnetic resonance images volumes in most cases.