# Deep learning-based reconstruction of highly accelerated 3D MRI

arXiv: https://arxiv.org/abs/2203.04674 · HTML: https://mlsanity.com/paper/2203.04674/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 9 of its 33 references that are in the map.
- First posted on arXiv 9 Mar 2022.

## Builds on (most cited first, 9 of 9)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [MoDL: Model Based Deep Learning Architecture for Inverse Problems](https://mlsanity.com/paper/1712.02862/) (2017)
- [Learning a Variational Network for Reconstruction of Accelerated MRI Data](https://mlsanity.com/paper/1704.00447/) (2017)
- [A Deep Cascade of Convolutional Neural Networks for Dynamic MR Image Reconstruction](https://mlsanity.com/paper/1704.02422/) (2017)
- [Image reconstruction by domain transform manifold learning](https://mlsanity.com/paper/1704.08841/) (2017)
- [Unrolled Optimization with Deep Priors](https://mlsanity.com/paper/1705.08041/) (2017)
- [An Adaptive Intelligence Algorithm for Undersampled Knee MRI Reconstruction](https://mlsanity.com/paper/2004.07339/) (2020)
- [High Fidelity Deep Learning-based MRI Reconstruction with Instance-wise Discriminative Feature Matching Loss](https://mlsanity.com/paper/2108.12460/) (2021)

## Built on by (most cited first, 2 of 2)

- [Computationally Efficient 3D MRI Reconstruction with Adaptive MLP](https://mlsanity.com/paper/2301.08868/) (2023)
- [Untrained Perceptual Loss for image denoising of line-like structures in MR images](https://mlsanity.com/paper/2411.05884/) (2024)

## Abstract (arXiv)

Purpose: To accelerate brain 3D MRI scans by using a deep learning method for reconstructing images from highly-undersampled multi-coil k-space data Methods: DL-Speed, an unrolled optimization architecture with dense skip-layer connections, was trained on 3D T1-weighted brain scan data to reconstruct complex-valued images from highly-undersampled k-space data. The trained model was evaluated on 3D MPRAGE brain scan data retrospectively-undersampled with a 10-fold acceleration, compared to a conventional parallel imaging method with a 2-fold acceleration. Scores of SNR, artifacts, gray/white matter contrast, resolution/sharpness, deep gray-matter, cerebellar vermis, anterior commissure, and overall quality, on a 5-point Likert scale, were assessed by experienced radiologists. In addition, the trained model was tested on retrospectively-undersampled 3D T1-weighted LAVA (Liver Acquisition with Volume Acceleration) abdominal scan data, and prospectively-undersampled 3D MPRAGE and LAVA scans in three healthy volunteers and one, respectively. Results: The qualitative scores for DL-Speed with a 10-fold acceleration were higher than or equal to those for the parallel imaging with 2-fold acceleration. DL-Speed outperformed a compressed sensing method in quantitative metrics on retrospectively-undersampled LAVA data. DL-Speed was demonstrated to perform reasonably well on prospectively-undersampled scan data, realizing a 2-5 times reduction in scan time. Conclusion: DL-Speed was shown to accelerate 3D MPRAGE and LAVA with up to a net 10-fold acceleration, achieving 2-5 times faster scans compared to conventional parallel imaging and acceleration, while maintaining diagnostic image quality and real-time reconstruction. The brain scan data-trained DL-Speed also performed well when reconstructing abdominal LAVA scan data, demonstrating versatility of the network.