# TransBTSV2: Towards Better and More Efficient Volumetric Segmentation of Medical Images

arXiv: https://arxiv.org/abs/2201.12785 · HTML: https://mlsanity.com/paper/2201.12785/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Builds on 49 of its 72 references that are in the map.
- First posted on arXiv 30 Jan 2022.

## Builds on (most cited first, 30 of 49)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Training data-efficient image transformers & distillation through attention](https://mlsanity.com/paper/2012.12877/) (2020)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Longformer: The Long-Document Transformer](https://mlsanity.com/paper/2004.05150/) (2020)
- [Quo Vadis, Action Recognition? A New Model and the Kinetics Dataset](https://mlsanity.com/paper/1705.07750/) (2017)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [Non-local Neural Networks](https://mlsanity.com/paper/1711.07971/) (2017)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutions](https://mlsanity.com/paper/2102.12122/) (2021)
- [Big Bird: Transformers for Longer Sequences](https://mlsanity.com/paper/2007.14062/) (2020)
- [Reformer: The Efficient Transformer](https://mlsanity.com/paper/2001.04451/) (2020)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Deformable Convolutional Networks](https://mlsanity.com/paper/1703.06211/) (2017)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Rethinking Semantic Segmentation from a Sequence-to-Sequence Perspective with Transformers](https://mlsanity.com/paper/2012.15840/) (2020)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Twins: Revisiting the Design of Spatial Attention in Vision Transformers](https://mlsanity.com/paper/2104.13840/) (2021)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentation](https://mlsanity.com/paper/2004.08790/) (2020)

## Built on by (most cited first, 7 of 7)

- [UniBrain: Universal Brain MRI Diagnosis with Hierarchical Knowledge-enhanced Pre-training](https://mlsanity.com/paper/2309.06828/) (2023)
- [Vision Transformers in Medical Imaging: A Review](https://mlsanity.com/paper/2211.10043/) (2022)
- [Multi-Modal Brain Tumor Segmentation via 3D Multi-Scale Self-attention and Cross-attention](https://mlsanity.com/paper/2504.09088/) (2025)
- [Prototype-Driven and Multi-Expert Integrated Multi-Modal MR Brain Tumor Image Segmentation](https://mlsanity.com/paper/2307.12180/) (2023)
- [Unsupervised Hybrid framework for ANomaly Detection (HAND) -- applied to Screening Mammogram](https://mlsanity.com/paper/2409.11534/) (2024)
- [Interpretable Deep Learning Framework for Improved Disease Classification in Medical Imaging](https://mlsanity.com/paper/2503.11851/) (2025)
- [Mix-modal Federated Learning for MRI Image Segmentation](https://mlsanity.com/paper/2509.02541/) (2025)

## Abstract (arXiv)

Transformer, benefiting from global (long-range) information modeling using self-attention mechanism, has been successful in natural language processing and computer vision recently. Convolutional Neural Networks, capable of capturing local features, are difficult to model explicit long-distance dependencies from global feature space. However, both local and global features are crucial for dense prediction tasks, especially for 3D medical image segmentation. In this paper, we present the further attempt to exploit Transformer in 3D CNN for 3D medical image volumetric segmentation and propose a novel network named TransBTSV2 based on the encoder-decoder structure. Different from TransBTS, the proposed TransBTSV2 is not limited to brain tumor segmentation (BTS) but focuses on general medical image segmentation, providing a stronger and more efficient 3D baseline for volumetric segmentation of medical images. As a hybrid CNN-Transformer architecture, TransBTSV2 can achieve accurate segmentation of medical images without any pre-training, possessing the strong inductive bias as CNNs and powerful global context modeling ability as Transformer. With the proposed insight to redesign the internal structure of Transformer block and the introduced Deformable Bottleneck Module to capture shape-aware local details, a highly efficient architecture is achieved with superior performance. Extensive experimental results on four medical image datasets (BraTS 2019, BraTS 2020, LiTS 2017 and KiTS 2019) demonstrate that TransBTSV2 achieves comparable or better results compared to the state-of-the-art methods for the segmentation of brain tumor, liver tumor as well as kidney tumor. Code will be publicly available at https://github.com/Wenxuan-1119/TransBTS.