# Label-dependent and event-guided interpretable disease risk prediction using EHRs

arXiv: https://arxiv.org/abs/2201.06783 · HTML: https://mlsanity.com/paper/2201.06783/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 9 of its 13 references that are in the map.
- First posted on arXiv 18 Jan 2022.

## Builds on (most cited first, 9 of 9)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [MDETR -- Modulated Detection for End-to-End Multi-Modal Understanding](https://mlsanity.com/paper/2104.12763/) (2021)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [Multitask learning and benchmarking with clinical time series data](https://mlsanity.com/paper/1703.07771/) (2017)
- [Explainable Prediction of Medical Codes from Clinical Text](https://mlsanity.com/paper/1802.05695/) (2018)
- [Joint Embedding of Words and Labels for Text Classification](https://mlsanity.com/paper/1805.04174/) (2018)
- [RAIM: Recurrent Attentive and Intensive Model of Multimodal Patient Monitoring Data](https://mlsanity.com/paper/1807.08820/) (2018)
- [Exploiting Convolutional Neural Network for Risk Prediction with Medical Feature Embedding](https://mlsanity.com/paper/1701.07474/) (2017)

## Built on by (most cited first, 1 of 1)

- [HoloDx: Knowledge- and Data-Driven Multimodal Diagnosis of Alzheimer's Disease](https://mlsanity.com/paper/2504.19075/) (2025)

## Abstract (arXiv)

Electronic health records (EHRs) contain patients' heterogeneous data that are collected from medical providers involved in the patient's care, including medical notes, clinical events, laboratory test results, symptoms, and diagnoses. In the field of modern healthcare, predicting whether patients would experience any risks based on their EHRs has emerged as a promising research area, in which artificial intelligence (AI) plays a key role. To make AI models practically applicable, it is required that the prediction results should be both accurate and interpretable. To achieve this goal, this paper proposed a label-dependent and event-guided risk prediction model (LERP) to predict the presence of multiple disease risks by mainly extracting information from unstructured medical notes. Our model is featured in the following aspects. First, we adopt a label-dependent mechanism that gives greater attention to words from medical notes that are semantically similar to the names of risk labels. Secondly, as the clinical events (e.g., treatments and drugs) can also indicate the health status of patients, our model utilizes the information from events and uses them to generate an event-guided representation of medical notes. Thirdly, both label-dependent and event-guided representations are integrated to make a robust prediction, in which the interpretability is enabled by the attention weights over words from medical notes. To demonstrate the applicability of the proposed method, we apply it to the MIMIC-III dataset, which contains real-world EHRs collected from hospitals. Our method is evaluated in both quantitative and qualitative ways.