# Negative Evidence Matters in Interpretable Histology Image Classification

arXiv: https://arxiv.org/abs/2201.02445 · HTML: https://mlsanity.com/paper/2201.02445/

## Key facts

- Cited by 8 papers in the map (data through 14 Oct 2026).
- Builds on 66 of its 104 references that are in the map.
- First posted on arXiv 7 Jan 2022.

## Builds on (most cited first, 30 of 66)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [Grad-CAM++: Improved Visual Explanations for Deep Convolutional Networks](https://mlsanity.com/paper/1710.11063/) (2017)
- [Interpretable Explanations of Black Boxes by Meaningful Perturbation](https://mlsanity.com/paper/1704.03296/) (2017)
- [Network In Network](https://mlsanity.com/paper/1312.4400/) (2013)
- [Learning from Noisy Labels with Deep Neural Networks: A Survey](https://mlsanity.com/paper/2007.08199/) (2020)
- [ScribbleSup: Scribble-Supervised Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1604.05144/) (2016)
- [Top-down Neural Attention by Excitation Backprop](https://mlsanity.com/paper/1608.00507/) (2016)
- [Self-supervised Equivariant Attention Mechanism for Weakly Supervised Semantic Segmentation](https://mlsanity.com/paper/2004.04581/) (2020)
- [What's the Point: Semantic Segmentation with Point Supervision](https://mlsanity.com/paper/1506.02106/) (2015)
- [Understanding Deep Networks via Extremal Perturbations and Smooth Masks](https://mlsanity.com/paper/1910.08485/) (2019)
- [BoxSup: Exploiting Bounding Boxes to Supervise Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1503.01640/) (2015)
- [Causal Intervention for Weakly-Supervised Semantic Segmentation](https://mlsanity.com/paper/2009.12547/) (2020)
- [Simple Does It: Weakly Supervised Instance and Semantic Segmentation](https://mlsanity.com/paper/1603.07485/) (2016)
- [Hide-and-Seek: Forcing a Network to be Meticulous for Weakly-supervised Object and Action Localization](https://mlsanity.com/paper/1704.04232/) (2017)
- [Object Region Mining with Adversarial Erasing: A Simple Classification to Semantic Segmentation Approach](https://mlsanity.com/paper/1703.08448/) (2017)
- [Seed, Expand and Constrain: Three Principles for Weakly-Supervised Image Segmentation](https://mlsanity.com/paper/1603.06098/) (2016)
- [Evaluating and Aggregating Feature-based Model Explanations](https://mlsanity.com/paper/2005.00631/) (2020)
- [Tell Me Where to Look: Guided Attention Inference Network](https://mlsanity.com/paper/1802.10171/) (2018)
- [Adversarial Complementary Learning for Weakly Supervised Object Localization](https://mlsanity.com/paper/1804.06962/) (2018)
- [FickleNet: Weakly and Semi-supervised Semantic Image Segmentation using Stochastic Inference](https://mlsanity.com/paper/1902.10421/) (2019)

## Built on by (most cited first, 8 of 8)

- [Discriminative Sampling of Proposals in Self-Supervised Transformers for Weakly Supervised Object Localization](https://mlsanity.com/paper/2209.09209/) (2022)
- [TCAM: Temporal Class Activation Maps for Object Localization in Weakly-Labeled Unconstrained Videos](https://mlsanity.com/paper/2208.14542/) (2022)
- [Guided Interpretable Facial Expression Recognition via Spatial Action Unit Cues](https://mlsanity.com/paper/2402.00281/) (2024)
- [DiPS: Discriminative Pseudo-Label Sampling with Self-Supervised Transformers for Weakly Supervised Object Localization](https://mlsanity.com/paper/2310.06196/) (2023)
- [CoLo-CAM: Class Activation Mapping for Object Co-Localization in Weakly-Labeled Unconstrained Videos](https://mlsanity.com/paper/2303.09044/) (2023)
- [Constrained Sampling for Class-Agnostic Weakly Supervised Object Localization](https://mlsanity.com/paper/2209.09195/) (2022)
- [Leveraging Transformers for Weakly Supervised Object Localization in Unconstrained Videos](https://mlsanity.com/paper/2407.06018/) (2024)
- [PixelCAM: Pixel Class Activation Mapping for Histology Image Classification and ROI Localization](https://mlsanity.com/paper/2503.24135/) (2025)

## Abstract (arXiv)

Using only global image-class labels, weakly-supervised learning methods, such as class activation mapping, allow training CNNs to jointly classify an image, and locate regions of interest associated with the predicted class. However, without any guidance at the pixel level, such methods may yield inaccurate regions. This problem is known to be more challenging with histology images than with natural ones, since objects are less salient, structures have more variations, and foreground and background regions have stronger similarities. Therefore, computer vision methods for visual interpretation of CNNs may not directly apply. In this paper, a simple yet efficient method based on a composite loss is proposed to learn information from the fully negative samples (i.e., samples without positive regions), and thereby reduce false positives/negatives. Our new loss function contains two complementary terms: the first exploits positive evidence collected from the CNN classifier, while the second leverages the fully negative samples from training data. In particular, a pre-trained CNN is equipped with a decoder that allows refining the regions of interest. The CNN is exploited to collect both positive and negative evidence at the pixel level to train the decoder. Our method called NEGEV benefits from the fully negative samples that naturally occur in the data, without any additional supervision signals beyond image-class labels. Extensive experiments show that our proposed method can substantial outperform related state-of-art methods on GlaS (public benchmark for colon cancer), and Camelyon16 (patch-based benchmark for breast cancer using three different backbones). Our results highlight the benefits of using both positive and negative evidence, the first obtained from a classifier, and the other naturally available in datasets.