# Robust End-to-End Focal Liver Lesion Detection using Unregistered Multiphase Computed Tomography Images

arXiv: https://arxiv.org/abs/2112.01535 · HTML: https://mlsanity.com/paper/2112.01535/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 29 of its 62 references that are in the map.
- First posted on arXiv 2 Dec 2021.

## Builds on (most cited first, 29 of 29)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [Feature Pyramid Networks for Object Detection](https://mlsanity.com/paper/1612.03144/) (2016)
- [SSD: Single Shot MultiBox Detector](https://mlsanity.com/paper/1512.02325/) (2015)
- [Sequence to Sequence Learning with Neural Networks](https://mlsanity.com/paper/1409.3215/) (2014)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [Deformable Convolutional Networks](https://mlsanity.com/paper/1703.06211/) (2017)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [Self-Attention Generative Adversarial Networks](https://mlsanity.com/paper/1805.08318/) (2018)
- [Natural TTS Synthesis by Conditioning WaveNet on Mel Spectrogram Predictions](https://mlsanity.com/paper/1712.05884/) (2017)
- [Deformable ConvNets v2: More Deformable, Better Results](https://mlsanity.com/paper/1811.11168/) (2018)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images](https://mlsanity.com/paper/1808.08114/) (2018)
- [An Unsupervised Learning Model for Deformable Medical Image Registration](https://mlsanity.com/paper/1802.02604/) (2018)
- [Multi-scale self-guided attention for medical image segmentation](https://mlsanity.com/paper/1906.02849/) (2019)
- [PixelLink: Detecting Scene Text via Instance Segmentation](https://mlsanity.com/paper/1801.01315/) (2018)
- [Abdominal multi-organ segmentation with organ-attention networks and statistical fusion](https://mlsanity.com/paper/1804.08414/) (2018)
- [Automatic Liver and Lesion Segmentation in CT Using Cascaded Fully Convolutional Neural Networks and 3D Conditional Random Fields](https://mlsanity.com/paper/1610.02177/) (2016)
- [Image-and-Spatial Transformer Networks for Structure-Guided Image Registration](https://mlsanity.com/paper/1907.09200/) (2019)
- [Improving RetinaNet for CT Lesion Detection with Dense Masks from Weak RECIST Labels](https://mlsanity.com/paper/1906.02283/) (2019)
- [Automatic Liver and Tumor Segmentation of CT and MRI Volumes using Cascaded Fully Convolutional Neural Networks](https://mlsanity.com/paper/1702.05970/) (2017)
- [Unsupervised Deformable Image Registration Using Cycle-Consistent CNN](https://mlsanity.com/paper/1907.01319/) (2019)
- [Automatic Liver Lesion Segmentation Using A Deep Convolutional Neural Network Method](https://mlsanity.com/paper/1704.07239/) (2017)
- [Liver Lesion Detection from Weakly-labeled Multi-phase CT Volumes with a Grouped Single Shot MultiBox Detector](https://mlsanity.com/paper/1807.00436/) (2018)

## Built on by (most cited first, 1 of 1)

- [Is attention all you need in medical image analysis? A review](https://mlsanity.com/paper/2307.12775/) (2023)

## Abstract (arXiv)

The computer-aided diagnosis of focal liver lesions (FLLs) can help improve workflow and enable correct diagnoses; FLL detection is the first step in such a computer-aided diagnosis. Despite the recent success of deep-learning-based approaches in detecting FLLs, current methods are not sufficiently robust for assessing misaligned multiphase data. By introducing an attention-guided multiphase alignment in feature space, this study presents a fully automated, end-to-end learning framework for detecting FLLs from multiphase computed tomography (CT) images. Our method is robust to misaligned multiphase images owing to its complete learning-based approach, which reduces the sensitivity of the model's performance to the quality of registration and enables a standalone deployment of the model in clinical practice. Evaluation on a large-scale dataset with 280 patients confirmed that our method outperformed previous state-of-the-art methods and significantly reduced the performance degradation for detecting FLLs using misaligned multiphase CT images. The robustness of the proposed method can enhance the clinical adoption of the deep-learning-based computer-aided detection system.