# Localized Perturbations For Weakly-Supervised Segmentation of Glioma Brain Tumours

arXiv: https://arxiv.org/abs/2111.14953 · HTML: https://mlsanity.com/paper/2111.14953/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 9 of its 25 references that are in the map.
- First posted on arXiv 29 Nov 2021.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [RISE: Randomized Input Sampling for Explanation of Black-box Models](https://mlsanity.com/paper/1806.07421/) (2018)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [Self-Supervision with Superpixels: Training Few-shot Medical Image Segmentation without Annotation](https://mlsanity.com/paper/2007.09886/) (2020)
- [Hierarchical Attention Networks for Medical Image Segmentation](https://mlsanity.com/paper/1911.08777/) (2019)

## Built on by (most cited first, 2 of 2)

- [A Sneak Attack on Segmentation of Medical Images Using Deep Neural Network Classifiers](https://mlsanity.com/paper/2201.02771/) (2022)
- [Optimized Global Perturbation Attacks For Brain Tumour ROI Extraction From Binary Classification Models](https://mlsanity.com/paper/2211.04926/) (2022)

## Abstract (arXiv)

Deep convolutional neural networks (CNNs) have become an essential tool in the medical imaging-based computer-aided diagnostic pipeline. However, training accurate and reliable CNNs requires large fine-grain annotated datasets. To alleviate this, weakly-supervised methods can be used to obtain local information from global labels. This work proposes the use of localized perturbations as a weakly-supervised solution to extract segmentation masks of brain tumours from a pretrained 3D classification model. Furthermore, we propose a novel optimal perturbation method that exploits 3D superpixels to find the most relevant area for a given classification using a U-net architecture. Our method achieved a Dice similarity coefficient (DSC) of 0.44 when compared with expert annotations. When compared against Grad-CAM, our method outperformed both in visualization and localization ability of the tumour region, with Grad-CAM only achieving 0.11 average DSC.