# Fast and Light-Weight Network for Single Frame Structured Illumination Microscopy Super-Resolution

arXiv: https://arxiv.org/abs/2111.09103 · HTML: https://mlsanity.com/paper/2111.09103/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 32 references that are in the map.
- First posted on arXiv 17 Nov 2021.

## Builds on (most cited first, 16 of 16)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Image Super-Resolution Using Very Deep Residual Channel Attention Networks](https://mlsanity.com/paper/1807.02758/) (2018)
- [Deep Laplacian Pyramid Networks for Fast and Accurate Super-Resolution](https://mlsanity.com/paper/1704.03915/) (2017)
- [Selective Kernel Networks](https://mlsanity.com/paper/1903.06586/) (2019)
- [Toward Convolutional Blind Denoising of Real Photographs](https://mlsanity.com/paper/1807.04686/) (2018)
- [Moir'e Photo Restoration Using Multiresolution Convolutional Neural Networks](https://mlsanity.com/paper/1805.02996/) (2018)
- [Multi-scale Dynamic Feature Encoding Network for Image Demoireing](https://mlsanity.com/paper/1909.11947/) (2019)
- [Single-shot structured illumination microscopy](https://mlsanity.com/paper/2107.05930/) (2021)

## Built on by (most cited first, 1 of 1)

- [Recent Advancements in Microscopy Image Enhancement using Deep Learning: A Survey](https://mlsanity.com/paper/2509.15363/) (2025)

## Abstract (arXiv)

Structured illumination microscopy (SIM) is an important super-resolution based microscopy technique that breaks the diffraction limit and enhances optical microscopy systems. With the development of biology and medical engineering, there is a high demand for real-time and robust SIM imaging under extreme low light and short exposure environments. Existing SIM techniques typically require multiple structured illumination frames to produce a high-resolution image. In this paper, we propose a single-frame structured illumination microscopy (SF-SIM) based on deep learning. Our SF-SIM only needs one shot of a structured illumination frame and generates similar results compared with the traditional SIM systems that typically require 15 shots. In our SF-SIM, we propose a noise estimator which can effectively suppress the noise in the image and enable our method to work under the low light and short exposure environment, without the need for stacking multiple frames for non-local denoising. We also design a bandpass attention module that makes our deep network more sensitive to the change of frequency and enhances the imaging quality. Our proposed SF-SIM is almost 14 times faster than traditional SIM methods when achieving similar results. Therefore, our method is significantly valuable for the development of microbiology and medicine.