# Out of distribution detection for skin and malaria images

arXiv: https://arxiv.org/abs/2111.01505 · HTML: https://mlsanity.com/paper/2111.01505/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 43 references that are in the map.
- First posted on arXiv 2 Nov 2021.

## Builds on (most cited first, 20 of 20)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [A Baseline for Detecting Misclassified and Out-of-Distribution Examples in Neural Networks](https://mlsanity.com/paper/1610.02136/) (2016)
- [A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks](https://mlsanity.com/paper/1807.03888/) (2018)
- [Enhancing The Reliability of Out-of-distribution Image Detection in Neural Networks](https://mlsanity.com/paper/1706.02690/) (2017)
- [Deep Anomaly Detection with Outlier Exposure](https://mlsanity.com/paper/1812.04606/) (2018)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [Likelihood Ratios for Out-of-Distribution Detection](https://mlsanity.com/paper/1906.02845/) (2019)
- [CSI: Novelty Detection via Contrastive Learning on Distributionally Shifted Instances](https://mlsanity.com/paper/2007.08176/) (2020)
- [Generalized ODIN: Detecting Out-of-distribution Image without Learning from Out-of-distribution Data](https://mlsanity.com/paper/2002.11297/) (2020)
- [Re-ranking Person Re-identification with k-reciprocal Encoding](https://mlsanity.com/paper/1701.08398/) (2017)
- [Contrastive Training for Improved Out-of-Distribution Detection](https://mlsanity.com/paper/2007.05566/) (2020)
- [Skin Lesion Classification Using Ensembles of Multi-Resolution EfficientNets with Meta Data](https://mlsanity.com/paper/1910.03910/) (2019)
- [A Benchmark of Medical Out of Distribution Detection](https://mlsanity.com/paper/2007.04250/) (2020)
- [Detecting Out-of-Distribution Examples with In-distribution Examples and Gram Matrices](https://mlsanity.com/paper/1912.12510/) (2019)
- [Deep Learning Ensembles for Melanoma Recognition in Dermoscopy Images](https://mlsanity.com/paper/1610.04662/) (2016)
- [An adaptive nearest neighbor rule for classification](https://mlsanity.com/paper/1905.12717/) (2019)
- [Out of Distribution Detection and Adversarial Attacks on Deep Neural Networks for Robust Medical Image Analysis](https://mlsanity.com/paper/2107.04882/) (2021)

## Abstract (arXiv)

Deep neural networks have shown promising results in disease detection and classification using medical image data. However, they still suffer from the challenges of handling real-world scenarios especially reliably detecting out-of-distribution (OoD) samples. We propose an approach to robustly classify OoD samples in skin and malaria images without the need to access labeled OoD samples during training. Specifically, we use metric learning along with logistic regression to force the deep networks to learn much rich class representative features. To guide the learning process against the OoD examples, we generate ID similar-looking examples by either removing class-specific salient regions in the image or permuting image parts and distancing them away from in-distribution samples. During inference time, the K-reciprocal nearest neighbor is employed to detect out-of-distribution samples. For skin cancer OoD detection, we employ two standard benchmark skin cancer ISIC datasets as ID, and six different datasets with varying difficulty levels were taken as out of distribution. For malaria OoD detection, we use the BBBC041 malaria dataset as ID and five different challenging datasets as out of distribution. We achieved state-of-the-art results, improving 5% and 4% in TNR@TPR95% over the previous state-of-the-art for skin cancer and malaria OoD detection respectively.