# Drug Similarity and Link Prediction Using Graph Embeddings on Medical Knowledge Graphs

arXiv: https://arxiv.org/abs/2110.13047 · HTML: https://mlsanity.com/paper/2110.13047/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 26 references that are in the map.
- First posted on arXiv 22 Oct 2021.

## Builds on (most cited first, 11 of 11)

- [DeepWalk: Online Learning of Social Representations](https://mlsanity.com/paper/1403.6652/) (2014)
- [Embedding Entities and Relations for Learning and Inference in Knowledge Bases](https://mlsanity.com/paper/1412.6575/) (2014)
- [Complex Embeddings for Simple Link Prediction](https://mlsanity.com/paper/1606.06357/) (2016)
- [Link Prediction Based on Graph Neural Networks](https://mlsanity.com/paper/1802.09691/) (2018)
- [Convolutional 2D Knowledge Graph Embeddings](https://mlsanity.com/paper/1707.01476/) (2017)
- [Knowledge Graphs](https://mlsanity.com/paper/2003.02320/) (2020)
- [Holographic Embeddings of Knowledge Graphs](https://mlsanity.com/paper/1510.04935/) (2015)
- [Canonical Tensor Decomposition for Knowledge Base Completion](https://mlsanity.com/paper/1806.07297/) (2018)
- [A Novel Embedding Model for Knowledge Base Completion Based on Convolutional Neural Network](https://mlsanity.com/paper/1712.02121/) (2017)
- [Drug-Drug Interaction Prediction Based on Knowledge Graph Embeddings and Convolutional-LSTM Network](https://mlsanity.com/paper/1908.01288/) (2019)
- [Combining Two And Three-Way Embeddings Models for Link Prediction in Knowledge Bases](https://mlsanity.com/paper/1506.00999/) (2015)

## Abstract (arXiv)

The paper utilizes the graph embeddings generated for entities of a large biomedical database to perform link prediction to capture various new relationships among different entities. A novel node similarity measure is proposed that utilizes the graph embeddings and link prediction scores to find similarity scores among various drugs which can be used by the medical experts to recommend alternative drugs to avoid side effects from original one. Utilizing machine learning on knowledge graph for drug similarity and recommendation will be less costly and less time consuming with higher scalability as compared to traditional biomedical methods due to the dependency on costly medical equipment and experts of the latter ones.