# Single volume lung biomechanics from chest computed tomography using a mode preserving generative adversarial network

arXiv: https://arxiv.org/abs/2110.07878 · HTML: https://mlsanity.com/paper/2110.07878/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 5 of its 19 references that are in the map.
- First posted on arXiv 15 Oct 2021.

## Builds on (most cited first, 5 of 5)

- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Instance Normalization: The Missing Ingredient for Fast Stylization](https://mlsanity.com/paper/1607.08022/) (2016)
- [Least Squares Generative Adversarial Networks](https://mlsanity.com/paper/1611.04076/) (2016)
- [A General and Adaptive Robust Loss Function](https://mlsanity.com/paper/1701.03077/) (2017)
- [Discriminator Rejection Sampling](https://mlsanity.com/paper/1810.06758/) (2018)

## Built on by (most cited first, 2 of 2)

- [A Physics-Informed Low-Shot Learning For sEMG-Based Estimation of Muscle Force and Joint Kinematics](https://mlsanity.com/paper/2307.05361/) (2023)
- [Deep learning in medical image registration: introduction and survey](https://mlsanity.com/paper/2309.00727/) (2023)

## Abstract (arXiv)

Local tissue expansion of the lungs is typically derived by registering computed tomography (CT) scans acquired at multiple lung volumes. However, acquiring multiple scans incurs increased radiation dose, time, and cost, and may not be possible in many cases, thus restricting the applicability of registration-based biomechanics. We propose a generative adversarial learning approach for estimating local tissue expansion directly from a single CT scan. The proposed framework was trained and evaluated on 2500 subjects from the SPIROMICS cohort. Once trained, the framework can be used as a registration-free method for predicting local tissue expansion. We evaluated model performance across varying degrees of disease severity and compared its performance with two image-to-image translation frameworks - UNet and Pix2Pix. Our model achieved an overall PSNR of 18.95 decibels, SSIM of 0.840, and Spearman's correlation of 0.61 at a high spatial resolution of 1 mm3.