# A mathematical justification for metronomic chemotherapy in oncology

arXiv: https://arxiv.org/abs/2110.07250 · HTML: https://mlsanity.com/paper/2110.07250/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 14 Oct 2021.

## Built on by (most cited first, 1 of 1)

- [Forecasting COVID-19 spreading trough an ensemble of classical and machine learning models: Spain's case study](https://mlsanity.com/paper/2207.05753/) (2022)

## Abstract (arXiv)

We mathematically justify metronomic chemotherapy as the best strategy to apply most cytotoxic drugs in oncology for both curative and palliative approaches, assuming the classical pharmacokinetic model together with the Emax pharmacodynamic and the Norton-Simon hypothesis. From the mathematical point of view, we will consider two mixed-integer nonlinear optimization problems, where the unknowns are the number of the doses and the quantity of each one, adjusting the administration times a posteriori