# DecGAN: Decoupling Generative Adversarial Network detecting abnormal neural circuits for Alzheimer's disease

arXiv: https://arxiv.org/abs/2110.05712 · HTML: https://mlsanity.com/paper/2110.05712/

## Key facts

- Cited by 11 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 62 references that are in the map.
- First posted on arXiv 12 Oct 2021.

## Builds on (most cited first, 6 of 6)

- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [HNHN: Hypergraph Networks with Hyperedge Neurons](https://mlsanity.com/paper/2006.12278/) (2020)
- [Disease Prediction using Graph Convolutional Networks: Application to Autism Spectrum Disorder and Alzheimer's Disease](https://mlsanity.com/paper/1806.01738/) (2018)
- [Distance Metric Learning using Graph Convolutional Networks: Application to Functional Brain Networks](https://mlsanity.com/paper/1703.02161/) (2017)
- [Bidirectional Mapping Generative Adversarial Networks for Brain MR to PET Synthesis](https://mlsanity.com/paper/2008.03483/) (2020)
- [Tensorizing GAN with High-Order Pooling for Alzheimer's Disease Assessment](https://mlsanity.com/paper/2008.00748/) (2020)

## Built on by (most cited first, 11 of 11)

- [Brain Diffuser: An End-to-End Brain Image to Brain Network Pipeline](https://mlsanity.com/paper/2303.06410/) (2023)
- [Generative AI Enables EEG Super-Resolution via Spatio-Temporal Adaptive Diffusion Learning](https://mlsanity.com/paper/2407.03089/) (2024)
- [Applications of Generative Adversarial Networks in Neuroimaging and Clinical Neuroscience](https://mlsanity.com/paper/2206.07081/) (2022)
- [Adversarial Learning Based Structural Brain-network Generative Model for Analyzing Mild Cognitive Impairment](https://mlsanity.com/paper/2208.08896/) (2022)
- [GFE-Mamba: Mamba-based AD Multi-modal Progression Assessment via Generative Feature Extraction from MCI](https://mlsanity.com/paper/2407.15719/) (2024)
- [Cross-Modal Transformer GAN: A Brain Structure-Function Deep Fusing Framework for Alzheimer's Disease](https://mlsanity.com/paper/2206.13393/) (2022)
- [Hypergraph Neural Diffusion: A PDE-Inspired Framework for Hypergraph Message Passing](https://mlsanity.com/paper/2604.10955/) (2026)
- [ConnectomeDiffuser: Generative AI Enables Brain Network Construction from Diffusion Tensor Imaging](https://mlsanity.com/paper/2505.22683/) (2025)
- [Feature-selected Graph Spatial Attention Network for Addictive Brain-Networks Identification](https://mlsanity.com/paper/2207.00583/) (2022)
- [Dynamic Community Detection via Adversarial Temporal Graph Representation Learning](https://mlsanity.com/paper/2207.03580/) (2022)
- [BG-GAN: Generative AI Enable Representing Brain Structure-Function Connections for Alzheimer's Disease](https://mlsanity.com/paper/2309.08916/) (2023)

## Abstract (arXiv)

One of the main reasons for Alzheimer's disease (AD) is the disorder of some neural circuits. Existing methods for AD prediction have achieved great success, however, detecting abnormal neural circuits from the perspective of brain networks is still a big challenge. In this work, a novel decoupling generative adversarial network (DecGAN) is proposed to detect abnormal neural circuits for AD. Concretely, a decoupling module is designed to decompose a brain network into two parts: one part is composed of a few sparse graphs which represent the neural circuits largely determining the development of AD; the other part is a supplement graph, whose influence on AD can be ignored. Furthermore, the adversarial strategy is utilized to guide the decoupling module to extract the feature more related to AD. Meanwhile, by encoding the detected neural circuits to hypergraph data, an analytic module associated with the hyperedge neurons algorithm is designed to identify the neural circuits. More importantly, a novel sparse capacity loss based on the spatial-spectral hypergraph similarity is developed to minimize the intrinsic topological distribution of neural circuits, which can significantly improve the accuracy and robustness of the proposed model. Experimental results demonstrate that the proposed model can effectively detect the abnormal neural circuits at different stages of AD, which is helpful for pathological study and early treatment.