# Score-based diffusion models for accelerated MRI

arXiv: https://arxiv.org/abs/2110.05243 · HTML: https://mlsanity.com/paper/2110.05243/

## Key facts

- Cited by 311 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 40 of its 75 references that are in the map.
- First posted on arXiv 8 Oct 2021.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 40)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Progressive Growing of GANs for Improved Quality, Stability, and Variation](https://mlsanity.com/paper/1710.10196/) (2017)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [What Uncertainties Do We Need in Bayesian Deep Learning for Computer Vision?](https://mlsanity.com/paper/1703.04977/) (2017)
- [Fourier Features Let Networks Learn High Frequency Functions in Low Dimensional Domains](https://mlsanity.com/paper/2006.10739/) (2020)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [DiffWave: A Versatile Diffusion Model for Audio Synthesis](https://mlsanity.com/paper/2009.09761/) (2020)
- [Variational Diffusion Models](https://mlsanity.com/paper/2107.00630/) (2021)
- [Improved Techniques for Training Score-Based Generative Models](https://mlsanity.com/paper/2006.09011/) (2020)
- [Maximum Likelihood Training of Score-Based Diffusion Models](https://mlsanity.com/paper/2101.09258/) (2021)
- [ILVR: Conditioning Method for Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2108.02938/) (2021)
- [fastMRI: An Open Dataset and Benchmarks for Accelerated MRI](https://mlsanity.com/paper/1811.08839/) (2018)
- [Making Convolutional Networks Shift-Invariant Again](https://mlsanity.com/paper/1904.11486/) (2019)
- [Sliced Score Matching: A Scalable Approach to Density and Score Estimation](https://mlsanity.com/paper/1905.07088/) (2019)
- [Robust Compressed Sensing MRI with Deep Generative Priors](https://mlsanity.com/paper/2108.01368/) (2021)
- [How to Train Your Energy-Based Models](https://mlsanity.com/paper/2101.03288/) (2021)
- [Permutation Invariant Graph Generation via Score-Based Generative Modeling](https://mlsanity.com/paper/2003.00638/) (2020)

## Built on by (most cited first, 30 of 311)

- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Diffusion Models: A Comprehensive Survey of Methods and Applications](https://mlsanity.com/paper/2209.00796/) (2022)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [Come-Closer-Diffuse-Faster: Accelerating Conditional Diffusion Models for Inverse Problems through Stochastic Contraction](https://mlsanity.com/paper/2112.05146/) (2021)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [A Survey on Generative Diffusion Model](https://mlsanity.com/paper/2209.02646/) (2022)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [A Survey on Diffusion Models for Inverse Problems](https://mlsanity.com/paper/2410.00083/) (2024)
- [PTQD: Accurate Post-Training Quantization for Diffusion Models](https://mlsanity.com/paper/2305.10657/) (2023)
- [Generative Modelling With Inverse Heat Dissipation](https://mlsanity.com/paper/2206.13397/) (2022)
- [Improving Diffusion Inverse Problem Solving with Decoupled Noise Annealing](https://mlsanity.com/paper/2407.01521/) (2024)
- [Solving 3D Inverse Problems using Pre-trained 2D Diffusion Models](https://mlsanity.com/paper/2211.10655/) (2022)
- [Decomposed Diffusion Sampler for Accelerating Large-Scale Inverse Problems](https://mlsanity.com/paper/2303.05754/) (2023)
- [GENIE: Higher-Order Denoising Diffusion Solvers](https://mlsanity.com/paper/2210.05475/) (2022)
- [Score-Based Diffusion Models as Principled Priors for Inverse Imaging](https://mlsanity.com/paper/2304.11751/) (2023)
- [Adaptive Diffusion Priors for Accelerated MRI Reconstruction](https://mlsanity.com/paper/2207.05876/) (2022)
- [Parallel Diffusion Models of Operator and Image for Blind Inverse Problems](https://mlsanity.com/paper/2211.10656/) (2022)
- [TFG: Unified Training-Free Guidance for Diffusion Models](https://mlsanity.com/paper/2409.15761/) (2024)
- [Principled Probabilistic Imaging using Diffusion Models as Plug-and-Play Priors](https://mlsanity.com/paper/2405.18782/) (2024)
- [Exploring Chemical Space with Score-based Out-of-distribution Generation](https://mlsanity.com/paper/2206.07632/) (2022)
- [Constrained Synthesis with Projected Diffusion Models](https://mlsanity.com/paper/2402.03559/) (2024)
- [DOLCE: A Model-Based Probabilistic Diffusion Framework for Limited-Angle CT Reconstruction](https://mlsanity.com/paper/2211.12340/) (2022)
- [Diffusion Models in Low-Level Vision: A Survey](https://mlsanity.com/paper/2406.11138/) (2024)
- [An Overview of Diffusion Models: Applications, Guided Generation, Statistical Rates and Optimization](https://mlsanity.com/paper/2404.07771/) (2024)
- [Jailbreaking Prompt Attack: A Controllable Adversarial Attack against Diffusion Models](https://mlsanity.com/paper/2404.02928/) (2024)
- [Prompt-tuning latent diffusion models for inverse problems](https://mlsanity.com/paper/2310.01110/) (2023)
- [Generative AI for Medical Imaging: extending the MONAI Framework](https://mlsanity.com/paper/2307.15208/) (2023)
- [InverseBench: Benchmarking Plug-and-Play Diffusion Priors for Inverse Problems in Physical Sciences](https://mlsanity.com/paper/2503.11043/) (2025)
- [MR Image Denoising and Super-Resolution Using Regularized Reverse Diffusion](https://mlsanity.com/paper/2203.12621/) (2022)
- [Measurement-conditioned Denoising Diffusion Probabilistic Model for Under-sampled Medical Image Reconstruction](https://mlsanity.com/paper/2203.03623/) (2022)

## Abstract (arXiv)

Score-based diffusion models provide a powerful way to model images using the gradient of the data distribution. Leveraging the learned score function as a prior, here we introduce a way to sample data from a conditional distribution given the measurements, such that the model can be readily used for solving inverse problems in imaging, especially for accelerated MRI. In short, we train a continuous time-dependent score function with denoising score matching. Then, at the inference stage, we iterate between numerical SDE solver and data consistency projection step to achieve reconstruction. Our model requires magnitude images only for training, and yet is able to reconstruct complex-valued data, and even extends to parallel imaging. The proposed method is agnostic to sub-sampling patterns, and can be used with any sampling schemes. Also, due to its generative nature, our approach can quantify uncertainty, which is not possible with standard regression settings. On top of all the advantages, our method also has very strong performance, even beating the models trained with full supervision. With extensive experiments, we verify the superiority of our method in terms of quality and practicality.