# Interactive Segmentation for COVID-19 Infection Quantification on Longitudinal CT scans

arXiv: https://arxiv.org/abs/2110.00948 · HTML: https://mlsanity.com/paper/2110.00948/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 31 references that are in the map.
- First posted on arXiv 3 Oct 2021.

## Builds on (most cited first, 11 of 11)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [On the Convergence of Adam and Beyond](https://mlsanity.com/paper/1904.09237/) (2019)
- [Inf-Net: Automatic COVID-19 Lung Infection Segmentation from CT Images](https://mlsanity.com/paper/2004.14133/) (2020)
- [Deep Interactive Object Selection](https://mlsanity.com/paper/1603.04042/) (2016)
- [The One Hundred Layers Tiramisu: Fully Convolutional DenseNets for Semantic Segmentation](https://mlsanity.com/paper/1611.09326/) (2016)
- [Interactive Medical Image Segmentation using Deep Learning with Image-specific Fine-tuning](https://mlsanity.com/paper/1710.04043/) (2017)
- [QuickNAT: A Fully Convolutional Network for Quick and Accurate Segmentation of Neuroanatomy](https://mlsanity.com/paper/1801.04161/) (2018)
- [Multi-branch Convolutional Neural Network for Multiple Sclerosis Lesion Segmentation](https://mlsanity.com/paper/1811.02942/) (2018)
- [Spatio-temporal Learning from Longitudinal Data for Multiple Sclerosis Lesion Segmentation](https://mlsanity.com/paper/2004.03675/) (2020)
- [Longitudinal Quantitative Assessment of COVID-19 Infection Progression from Chest CTs](https://mlsanity.com/paper/2103.07240/) (2021)

## Built on by (most cited first, 2 of 2)

- [Deep Interactive Segmentation of Medical Images: A Systematic Review and Taxonomy](https://mlsanity.com/paper/2311.13964/) (2023)
- [Longitudinal Self-Supervision for COVID-19 Pathology Quantification](https://mlsanity.com/paper/2203.10804/) (2022)

## Abstract (arXiv)

Consistent segmentation of COVID-19 patient's CT scans across multiple time points is essential to assess disease progression and response to therapy accurately. Existing automatic and interactive segmentation models for medical images only use data from a single time point (static). However, valuable segmentation information from previous time points is often not used to aid the segmentation of a patient's follow-up scans. Also, fully automatic segmentation techniques frequently produce results that would need further editing for clinical use. In this work, we propose a new single network model for interactive segmentation that fully utilizes all available past information to refine the segmentation of follow-up scans. In the first segmentation round, our model takes 3D volumes of medical images from two-time points (target and reference) as concatenated slices with the additional reference time point segmentation as a guide to segment the target scan. In subsequent segmentation refinement rounds, user feedback in the form of scribbles that correct the segmentation and the target's previous segmentation results are additionally fed into the model. This ensures that the segmentation information from previous refinement rounds is retained. Experimental results on our in-house multiclass longitudinal COVID-19 dataset show that the proposed model outperforms its static version and can assist in localizing COVID-19 infections in patient's follow-up scans.