# Source-Free Domain Adaptive Fundus Image Segmentation with Denoised Pseudo-Labeling

arXiv: https://arxiv.org/abs/2109.09735 · HTML: https://mlsanity.com/paper/2109.09735/

## Key facts

- Cited by 61 papers in the map (data through 14 Oct 2026).
- Builds on 19 of its 28 references that are in the map.
- First posted on arXiv 19 Sep 2021.

## Builds on (most cited first, 19 of 19)

- [On Calibration of Modern Neural Networks](https://mlsanity.com/paper/1706.04599/) (2017)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [Prototypical Networks for Few-shot Learning](https://mlsanity.com/paper/1703.05175/) (2017)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [Unsupervised Bidirectional Cross-Modality Adaptation via Deeply Synergistic Image and Feature Alignment for Medical Image Segmentation](https://mlsanity.com/paper/2002.02255/) (2020)
- [Unsupervised domain adaptation in brain lesion segmentation with adversarial networks](https://mlsanity.com/paper/1612.08894/) (2016)
- [Test-Time Adaptable Neural Networks for Robust Medical Image Segmentation](https://mlsanity.com/paper/2004.04668/) (2020)
- [Translating and Segmenting Multimodal Medical Volumes with Cycle- and Shape-Consistency Generative Adversarial Network](https://mlsanity.com/paper/1802.09655/) (2018)
- [Unsupervised domain adaptation for medical imaging segmentation with self-ensembling](https://mlsanity.com/paper/1811.06042/) (2018)
- [SynSeg-Net: Synthetic Segmentation Without Target Modality Ground Truth](https://mlsanity.com/paper/1810.06498/) (2018)
- [Transfer Learning for Domain Adaptation in MRI: Application in Brain Lesion Segmentation](https://mlsanity.com/paper/1702.07841/) (2017)
- [Source-Relaxed Domain Adaptation for Image Segmentation](https://mlsanity.com/paper/2005.03697/) (2020)
- [Task Driven Generative Modeling for Unsupervised Domain Adaptation: Application to X-ray Image Segmentation](https://mlsanity.com/paper/1806.07201/) (2018)
- [Boundary and Entropy-driven Adversarial Learning for Fundus Image Segmentation](https://mlsanity.com/paper/1906.11143/) (2019)
- [Test-time Unsupervised Domain Adaptation](https://mlsanity.com/paper/2010.01926/) (2020)
- [Self domain adapted network](https://mlsanity.com/paper/2007.03162/) (2020)
- [Leveraging Regular Fundus Images for Training UWF Fundus Diagnosis Models via Adversarial Learning and Pseudo-Labeling](https://mlsanity.com/paper/2011.13816/) (2020)

## Built on by (most cited first, 30 of 61)

- [A Comprehensive Survey on Test-Time Adaptation under Distribution Shifts](https://mlsanity.com/paper/2303.15361/) (2023)
- [Source-Free Unsupervised Domain Adaptation: A Survey](https://mlsanity.com/paper/2301.00265/) (2022)
- [REFUGE2 Challenge: A Treasure Trove for Multi-Dimension Analysis and Evaluation in Glaucoma Screening](https://mlsanity.com/paper/2202.08994/) (2022)
- [On-the-Fly Test-time Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/2203.05574/) (2022)
- [DLTTA: Dynamic Learning Rate for Test-time Adaptation on Cross-domain Medical Images](https://mlsanity.com/paper/2205.13723/) (2022)
- [MAPSeg: Unified Unsupervised Domain Adaptation for Heterogeneous Medical Image Segmentation Based on 3D Masked Autoencoding and Pseudo-Labeling](https://mlsanity.com/paper/2303.09373/) (2023)
- [Dual-Reference Source-Free Active Domain Adaptation for Nasopharyngeal Carcinoma Tumor Segmentation across Multiple Hospitals](https://mlsanity.com/paper/2309.13401/) (2023)
- [Deep learning for unsupervised domain adaptation in medical imaging: Recent advancements and future perspectives](https://mlsanity.com/paper/2308.01265/) (2023)
- [Source-free unsupervised domain adaptation for cross-modality abdominal multi-organ segmentation](https://mlsanity.com/paper/2111.12221/) (2021)
- [Single-domain Generalization in Medical Image Segmentation via Test-time Adaptation from Shape Dictionary](https://mlsanity.com/paper/2206.14467/) (2022)
- [FVP: Fourier Visual Prompting for Source-Free Unsupervised Domain Adaptation of Medical Image Segmentation](https://mlsanity.com/paper/2304.13672/) (2023)
- [Source-Free Domain Adaptive Fundus Image Segmentation with Class-Balanced Mean Teacher](https://mlsanity.com/paper/2307.09973/) (2023)
- [From Denoising Training to Test-Time Adaptation: Enhancing Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2310.20271/) (2023)
- [ProSFDA: Prompt Learning based Source-free Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/2211.11514/) (2022)
- [Active Test-Time Adaptation: Theoretical Analyses and An Algorithm](https://mlsanity.com/paper/2404.05094/) (2024)
- [Memory Consistent Unsupervised Off-the-Shelf Model Adaptation for Source-Relaxed Medical Image Segmentation](https://mlsanity.com/paper/2209.07910/) (2022)
- [Source-Free Domain Adaptation for Medical Image Segmentation via Prototype-Anchored Feature Alignment and Contrastive Learning](https://mlsanity.com/paper/2307.09769/) (2023)
- [Uncertainty Quantification for Machine Learning in Healthcare: A Survey](https://mlsanity.com/paper/2505.02874/) (2025)
- [Target and Task specific Source-Free Domain Adaptive Image Segmentation](https://mlsanity.com/paper/2203.15792/) (2022)
- [Advancing UWF-SLO Vessel Segmentation with Source-Free Active Domain Adaptation and a Novel Multi-Center Dataset](https://mlsanity.com/paper/2406.13645/) (2024)
- [Anatomy-guided domain adaptation for 3D in-bed human pose estimation](https://mlsanity.com/paper/2211.12193/) (2022)
- [Towards Source-free Domain Adaptive Semantic Segmentation via Importance-aware and Prototype-contrast Learning](https://mlsanity.com/paper/2306.01598/) (2023)
- [Online Reflective Learning for Robust Medical Image Segmentation](https://mlsanity.com/paper/2207.00476/) (2022)
- [Generative appearance replay for continual unsupervised domain adaptation](https://mlsanity.com/paper/2301.01211/) (2023)
- [Self-Taught Recognizer: Toward Unsupervised Adaptation for Speech Foundation Models](https://mlsanity.com/paper/2405.14161/) (2024)
- [Context-Aware Pseudo-Label Refinement for Source-Free Domain Adaptive Fundus Image Segmentation](https://mlsanity.com/paper/2308.07731/) (2023)
- [Unsupervised Domain Adaptive Fundus Image Segmentation with Category-level Regularization](https://mlsanity.com/paper/2207.03684/) (2022)
- [A Chebyshev Confidence Guided Source-Free Domain Adaptation Framework for Medical Image Segmentation](https://mlsanity.com/paper/2310.18087/) (2023)
- [Medical Image Segmentation with Domain Adaptation: A Survey](https://mlsanity.com/paper/2311.01702/) (2023)
- [An Uncertainty-guided Tiered Self-training Framework for Active Source-free Domain Adaptation in Prostate Segmentation](https://mlsanity.com/paper/2407.02893/) (2024)

## Abstract (arXiv)

Domain adaptation typically requires to access source domain data to utilize their distribution information for domain alignment with the target data. However, in many real-world scenarios, the source data may not be accessible during the model adaptation in the target domain due to privacy issue. This paper studies the practical yet challenging source-free unsupervised domain adaptation problem, in which only an existing source model and the unlabeled target data are available for model adaptation. We present a novel denoised pseudo-labeling method for this problem, which effectively makes use of the source model and unlabeled target data to promote model self-adaptation from pseudo labels. Importantly, considering that the pseudo labels generated from source model are inevitably noisy due to domain shift, we further introduce two complementary pixel-level and class-level denoising schemes with uncertainty estimation and prototype estimation to reduce noisy pseudo labels and select reliable ones to enhance the pseudo-labeling efficacy. Experimental results on cross-domain fundus image segmentation show that without using any source images or altering source training, our approach achieves comparable or even higher performance than state-of-the-art source-dependent unsupervised domain adaptation methods.