# Automatic hippocampal surface generation via 3D U-net and active shape modeling with hybrid particle swarm optimization

arXiv: https://arxiv.org/abs/2109.06817 · HTML: https://mlsanity.com/paper/2109.06817/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 2 of its 15 references that are in the map.
- First posted on arXiv 14 Sep 2021.

## Builds on (most cited first, 2 of 2)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)

## Abstract (arXiv)

In this paper, we proposed and validated a fully automatic pipeline for hippocampal surface generation via 3D U-net coupled with active shape modeling (ASM). Principally, the proposed pipeline consisted of three steps. In the beginning, for each magnetic resonance image, a 3D U-net was employed to obtain the automatic hippocampus segmentation at each hemisphere. Secondly, ASM was performed on a group of pre-obtained template surfaces to generate mean shape and shape variation parameters through principal component analysis. Ultimately, hybrid particle swarm optimization was utilized to search for the optimal shape variation parameters that best match the segmentation. The hippocampal surface was then generated from the mean shape and the shape variation parameters. The proposed pipeline was observed to provide hippocampal surfaces at both hemispheres with high accuracy, correct anatomical topology, and sufficient smoothness.