# Towards Interpreting Zoonotic Potential of Betacoronavirus Sequences With Attention

arXiv: https://arxiv.org/abs/2108.08077 · HTML: https://mlsanity.com/paper/2108.08077/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 35 references that are in the map.
- First posted on arXiv 18 Aug 2021.

## Builds on (most cited first, 6 of 6)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Effective Approaches to Attention-based Neural Machine Translation](https://mlsanity.com/paper/1508.04025/) (2015)
- [Attention in Natural Language Processing](https://mlsanity.com/paper/1902.02181/) (2019)
- [BERTology Meets Biology: Interpreting Attention in Protein Language Models](https://mlsanity.com/paper/2006.15222/) (2020)

## Abstract (arXiv)

Current methods for viral discovery target evolutionarily conserved proteins that accurately identify virus families but remain unable to distinguish the zoonotic potential of newly discovered viruses. Here, we apply an attention-enhanced long-short-term memory (LSTM) deep neural net classifier to a highly conserved viral protein target to predict zoonotic potential across betacoronaviruses. The classifier performs with a 94% accuracy. Analysis and visualization of attention at the sequence and structure-level features indicate possible association between important protein-protein interactions governing viral replication in zoonotic betacoronaviruses and zoonotic transmission.