# Cervical Optical Coherence Tomography Image Classification Based on Contrastive Self-Supervised Texture Learning

arXiv: https://arxiv.org/abs/2108.05081 · HTML: https://mlsanity.com/paper/2108.05081/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 47 references that are in the map.
- First posted on arXiv 11 Aug 2021.

## Builds on (most cited first, 15 of 15)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [SCA-CNN: Spatial and Channel-wise Attention in Convolutional Networks for Image Captioning](https://mlsanity.com/paper/1611.05594/) (2016)
- [3D Self-Supervised Methods for Medical Imaging](https://mlsanity.com/paper/2006.03829/) (2020)
- [Cervical Cytology Classification Using PCA & GWO Enhanced Deep Features Selection](https://mlsanity.com/paper/2106.04919/) (2021)
- [Computer-aided diagnosis in histopathological images of the endometrium using a convolutional neural network and attention mechanisms](https://mlsanity.com/paper/1904.10626/) (2019)
- [Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue](https://mlsanity.com/paper/1809.10196/) (2018)

## Built on by (most cited first, 1 of 1)

- [A Review of Predictive and Contrastive Self-supervised Learning for Medical Images](https://mlsanity.com/paper/2302.05043/) (2023)

## Abstract (arXiv)

Background: Cervical cancer seriously affects the health of the female reproductive system. Optical coherence tomography (OCT) emerged as a non-invasive, high-resolution imaging technology for cervical disease detection. However, OCT image annotation is knowledge-intensive and time-consuming, which impedes the training process of deep-learning-based classification models. Purpose: This study aims to develop a computer-aided diagnosis (CADx) approach to classifying in-vivo cervical OCT images based on self-supervised learning. Methods: In addition to high-level semantic features extracted by a convolutional neural network (CNN), the proposed CADx approach leverages unlabeled cervical OCT images' texture features learned by contrastive texture learning. We conducted ten-fold cross-validation on the OCT image dataset from a multi-center clinical study on 733 patients from China. Results: In a binary classification task for detecting high-risk diseases, including high-grade squamous intraepithelial lesion and cervical cancer, our method achieved an area-under-the-curve value of 0.9798 plus or minus 0.0157 with a sensitivity of 91.17 plus or minus 4.99% and a specificity of 93.96 plus or minus 4.72% for OCT image patches; also, it outperformed two out of four medical experts on the test set. Furthermore, our method achieved a 91.53% sensitivity and 97.37% specificity on an external validation dataset containing 287 3D OCT volumes from 118 Chinese patients in a new hospital using a cross-shaped threshold voting strategy. Conclusions: The proposed contrastive-learning-based CADx method outperformed the end-to-end CNN models and provided better interpretability based on texture features, which holds great potential to be used in the clinical protocol of "see-and-treat."