# Redesigning Fully Convolutional DenseUNets for Large Histopathology Images

arXiv: https://arxiv.org/abs/2108.02676 · HTML: https://mlsanity.com/paper/2108.02676/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 25 references that are in the map.
- First posted on arXiv 5 Aug 2021.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Fast and Accurate Deep Network Learning by Exponential Linear Units (ELUs)](https://mlsanity.com/paper/1511.07289/) (2015)
- [Batch Renormalization: Towards Reducing Minibatch Dependence in Batch-Normalized Models](https://mlsanity.com/paper/1702.03275/) (2017)
- [The Importance of Skip Connections in Biomedical Image Segmentation](https://mlsanity.com/paper/1608.04117/) (2016)
- [The One Hundred Layers Tiramisu: Fully Convolutional DenseNets for Semantic Segmentation](https://mlsanity.com/paper/1611.09326/) (2016)

## Abstract (arXiv)

The automated segmentation of cancer tissue in histopathology images can help clinicians to detect, diagnose, and analyze such disease. Different from other natural images used in many convolutional networks for benchmark, histopathology images can be extremely large, and the cancerous patterns can reach beyond 1000 pixels. Therefore, the well-known networks in the literature were never conceived to handle these peculiarities. In this work, we propose a Fully Convolutional DenseUNet that is particularly designed to solve histopathology problems. We evaluated our network in two public pathology datasets published as challenges in the recent MICCAI 2019: binary segmentation in colon cancer images (DigestPath2019), and multi-class segmentation in prostate cancer images (Gleason2019), achieving similar and better results than the winners of the challenges, respectively. Furthermore, we discussed some good practices in the training setup to yield the best performance and the main challenges in these histopathology datasets.