# Realistic Ultrasound Image Synthesis for Improved Classification of Liver Disease

arXiv: https://arxiv.org/abs/2107.12775 · HTML: https://mlsanity.com/paper/2107.12775/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 8 of its 29 references that are in the map.
- First posted on arXiv 27 Jul 2021.

## Builds on (most cited first, 8 of 8)

- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks](https://mlsanity.com/paper/1511.06434/) (2015)
- [Spectral Normalization for Generative Adversarial Networks](https://mlsanity.com/paper/1802.05957/) (2018)
- [Self-Attention Generative Adversarial Networks](https://mlsanity.com/paper/1805.08318/) (2018)
- [Generative Adversarial Network in Medical Imaging: A Review](https://mlsanity.com/paper/1809.07294/) (2018)
- [GANs for Medical Image Analysis](https://mlsanity.com/paper/1809.06222/) (2018)
- [Data Augmentation for Skin Lesion using Self-Attention based Progressive Generative Adversarial Network](https://mlsanity.com/paper/1910.11960/) (2019)

## Built on by (most cited first, 5 of 5)

- [Generative AI for Synthetic Data Across Multiple Medical Modalities: A Systematic Review of Recent Developments and Challenges](https://mlsanity.com/paper/2407.00116/) (2024)
- [Ultrasound Image-to-Video Synthesis via Latent Dynamic Diffusion Models](https://mlsanity.com/paper/2503.14966/) (2025)
- [Improving Nonalcoholic Fatty Liver Disease Classification Performance With Latent Diffusion Models](https://mlsanity.com/paper/2307.06507/) (2023)
- [CSG: A Context-Semantic Guided Diffusion Approach in De Novo Musculoskeletal Ultrasound Image Generation](https://mlsanity.com/paper/2412.05833/) (2024)
- [OnUVS: Online Feature Decoupling Framework for High-Fidelity Ultrasound Video Synthesis](https://mlsanity.com/paper/2308.08269/) (2023)

## Abstract (arXiv)

With the success of deep learning-based methods applied in medical image analysis, convolutional neural networks (CNNs) have been investigated for classifying liver disease from ultrasound (US) data. However, the scarcity of available large-scale labeled US data has hindered the success of CNNs for classifying liver disease from US data. In this work, we propose a novel generative adversarial network (GAN) architecture for realistic diseased and healthy liver US image synthesis. We adopt the concept of stacking to synthesize realistic liver US data. Quantitative and qualitative evaluation is performed on 550 in-vivo B-mode liver US images collected from 55 subjects. We also show that the synthesized images, together with real in vivo data, can be used to significantly improve the performance of traditional CNN architectures for Nonalcoholic fatty liver disease (NAFLD) classification.