# Self-transfer learning via patches: A prostate cancer triage approach based on bi-parametric MRI

arXiv: https://arxiv.org/abs/2107.10806 · HTML: https://mlsanity.com/paper/2107.10806/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 47 references that are in the map.
- First posted on arXiv 22 Jul 2021.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning](https://mlsanity.com/paper/1711.05225/) (2017)
- [Transfusion: Understanding Transfer Learning for Medical Imaging](https://mlsanity.com/paper/1902.07208/) (2019)
- [Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning](https://mlsanity.com/paper/1602.03409/) (2016)
- [End-to-end Training for Whole Image Breast Cancer Diagnosis using An All Convolutional Design](https://mlsanity.com/paper/1711.05775/) (2017)
- [Prostate Cancer Detection using Deep Convolutional Neural Networks](https://mlsanity.com/paper/1905.13145/) (2019)
- [Prostate Cancer Diagnosis using Deep Learning with 3D Multiparametric MRI](https://mlsanity.com/paper/1703.04078/) (2017)
- [Improving prostate whole gland segmentation in t2-weighted MRI with synthetically generated data](https://mlsanity.com/paper/2103.14955/) (2021)
- [A Comprehensive Study of Data Augmentation Strategies for Prostate Cancer Detection in Diffusion-weighted MRI using Convolutional Neural Networks](https://mlsanity.com/paper/2006.01693/) (2020)

## Abstract (arXiv)

Prostate cancer (PCa) is the second most common cancer diagnosed among men worldwide. The current PCa diagnostic pathway comes at the cost of substantial overdiagnosis, leading to unnecessary treatment and further testing. Bi-parametric magnetic resonance imaging (bp-MRI) based on apparent diffusion coefficient maps (ADC) and T2-weighted (T2w) sequences has been proposed as a triage test to differentiate between clinically significant (cS) and non-clinically significant (ncS) prostate lesions. However, analysis of the sequences relies on expertise, requires specialized training, and suffers from inter-observer variability. Deep learning (DL) techniques hold promise in tasks such as classification and detection. Nevertheless, they rely on large amounts of annotated data which is not common in the medical field. In order to palliate such issues, existing works rely on transfer learning (TL) and ImageNet pre-training, which has been proven to be sub-optimal for the medical imaging domain. In this paper, we present a patch-based pre-training strategy to distinguish between cS and ncS lesions which exploit the region of interest (ROI) of the patched source domain to efficiently train a classifier in the full-slice target domain which does not require annotations by making use of transfer learning (TL). We provide a comprehensive comparison between several CNNs architectures and different settings which are presented as a baseline. Moreover, we explore cross-domain TL which exploits both MRI modalities and improves single modality results. Finally, we show how our approaches outperform the standard approaches by a considerable margin