# Data-driven mapping between functional connectomes using optimal transport

arXiv: https://arxiv.org/abs/2107.01303 · HTML: https://mlsanity.com/paper/2107.01303/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 27 references that are in the map.
- First posted on arXiv 2 Jul 2021.

## Builds on (most cited first, 3 of 3)

- [Computational Optimal Transport](https://mlsanity.com/paper/1803.00567/) (2018)
- [Near-linear time approximation algorithms for optimal transport via Sinkhorn iteration](https://mlsanity.com/paper/1705.09634/) (2017)
- [Optimal spectral transportation with application to music transcription](https://mlsanity.com/paper/1609.09799/) (2016)

## Abstract (arXiv)

Functional connectomes derived from functional magnetic resonance imaging have long been used to understand the functional organization of the brain. Nevertheless, a connectome is intrinsically linked to the atlas used to create it. In other words, a connectome generated from one atlas is different in scale and resolution compared to a connectome generated from another atlas. Being able to map connectomes and derived results between different atlases without additional pre-processing is a crucial step in improving interpretation and generalization between studies that use different atlases. Here, we use optimal transport, a powerful mathematical technique, to find an optimum mapping between two atlases. This mapping is then used to transform time series from one atlas to another in order to reconstruct a connectome. We validate our approach by comparing transformed connectomes against their "gold-standard" counterparts (i.e., connectomes generated directly from an atlas) and demonstrate the utility of transformed connectomes by applying these connectomes to predictive models based on a different atlas. We show that these transformed connectomes are significantly similar to their "gold-standard" counterparts and maintain individual differences in brain-behavior associations, demonstrating both the validity of our approach and its utility in downstream analyses. Overall, our approach is a promising avenue to increase the generalization of connectome-based results across different atlases.