# Unsupervised Detection of Cancerous Regions in Histology Imagery using Image-to-Image Translation

arXiv: https://arxiv.org/abs/2104.13786 · HTML: https://mlsanity.com/paper/2104.13786/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 18 of its 32 references that are in the map.
- First posted on arXiv 28 Apr 2021.

## Builds on (most cited first, 18 of 18)

- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [Multimodal Unsupervised Image-to-Image Translation](https://mlsanity.com/paper/1804.04732/) (2018)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [GANomaly: Semi-Supervised Anomaly Detection via Adversarial Training](https://mlsanity.com/paper/1805.06725/) (2018)
- [Uninformed Students: Student-Teacher Anomaly Detection with Discriminative Latent Embeddings](https://mlsanity.com/paper/1911.02357/) (2019)
- [DRIT++: Diverse Image-to-Image Translation via Disentangled Representations](https://mlsanity.com/paper/1905.01270/) (2019)
- [Suggestive Annotation: A Deep Active Learning Framework for Biomedical Image Segmentation](https://mlsanity.com/paper/1706.04737/) (2017)
- [Deep Autoencoding Models for Unsupervised Anomaly Segmentation in Brain MR Images](https://mlsanity.com/paper/1804.04488/) (2018)
- [Segmentation-Based Deep-Learning Approach for Surface-Defect Detection](https://mlsanity.com/paper/1903.08536/) (2019)
- [Skip-GANomaly: Skip Connected and Adversarially Trained Encoder-Decoder Anomaly Detection](https://mlsanity.com/paper/1901.08954/) (2019)
- [CycleGAN, a Master of Steganography](https://mlsanity.com/paper/1712.02950/) (2017)
- [Cascaded V-Net using ROI masks for brain tumor segmentation](https://mlsanity.com/paper/1812.11588/) (2018)
- [Scale-Space Autoencoders for Unsupervised Anomaly Segmentation in Brain MRI](https://mlsanity.com/paper/2006.12852/) (2020)
- [Few-Shot Anomaly Detection for Polyp Frames from Colonoscopy](https://mlsanity.com/paper/2006.14811/) (2020)
- [Manifolds for Unsupervised Visual Anomaly Detection](https://mlsanity.com/paper/2006.11364/) (2020)

## Built on by (most cited first, 4 of 4)

- [AI-based Anomaly Detection for Clinical-Grade Histopathological Diagnostics](https://mlsanity.com/paper/2406.14866/) (2024)
- [Learning to Generalize over Subpartitions for Heterogeneity-aware Domain Adaptive Nuclei Segmentation](https://mlsanity.com/paper/2401.09496/) (2024)
- [Segmentation of Multiple Myeloma Plasma Cells in Microscopy Images with Noisy Labels](https://mlsanity.com/paper/2111.05125/) (2021)
- [Additive Class Distinction Maps using Branched-GANs](https://mlsanity.com/paper/2305.02899/) (2023)

## Abstract (arXiv)

Detection of visual anomalies refers to the problem of finding patterns in different imaging data that do not conform to the expected visual appearance and is a widely studied problem in different domains. Due to the nature of anomaly occurrences and underlying generating processes, it is hard to characterize them and obtain labeled data. Obtaining labeled data is especially difficult in biomedical applications, where only trained domain experts can provide labels, which often come in large diversity and complexity. Recently presented approaches for unsupervised detection of visual anomalies approaches omit the need for labeled data and demonstrate promising results in domains, where anomalous samples significantly deviate from the normal appearance. Despite promising results, the performance of such approaches still lags behind supervised approaches and does not provide a one-fits-all solution. In this work, we present an image-to-image translation-based framework that significantly surpasses the performance of existing unsupervised methods and approaches the performance of supervised methods in a challenging domain of cancerous region detection in histology imagery.