# A Semi-Supervised Classification Method of Apicomplexan Parasites and Host Cell Using Contrastive Learning Strategy

arXiv: https://arxiv.org/abs/2104.06593 · HTML: https://mlsanity.com/paper/2104.06593/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 22 references that are in the map.
- First posted on arXiv 14 Apr 2021.

## Builds on (most cited first, 9 of 9)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Temporal Ensembling for Semi-Supervised Learning](https://mlsanity.com/paper/1610.02242/) (2016)
- [Virtual Adversarial Training: A Regularization Method for Supervised and Semi-Supervised Learning](https://mlsanity.com/paper/1704.03976/) (2017)
- [k-Sparse Autoencoders](https://mlsanity.com/paper/1312.5663/) (2013)
- [Applications of Deep Learning and Reinforcement Learning to Biological Data](https://mlsanity.com/paper/1711.03985/) (2017)

## Abstract (arXiv)

A common shortfall of supervised learning for medical imaging is the greedy need for human annotations, which is often expensive and time-consuming to obtain. This paper proposes a semi-supervised classification method for three kinds of apicomplexan parasites and non-infected host cells microscopic images, which uses a small number of labeled data and a large number of unlabeled data for training. There are two challenges in microscopic image recognition. The first is that salient structures of the microscopic images are more fuzzy and intricate than natural images' on a real-world scale. The second is that insignificant textures, like background staining, lightness, and contrast level, vary a lot in samples from different clinical scenarios. To address these challenges, we aim to learn a distinguishable and appearance-invariant representation by contrastive learning strategy. On one hand, macroscopic images, which share similar shape characteristics in morphology, are introduced to contrast for structure enhancement. On the other hand, different appearance transformations, including color distortion and flittering, are utilized to contrast for texture elimination. In the case where only 1% of microscopic images are labeled, the proposed method reaches an accuracy of 94.90% in a generalized testing set.