# Forest Fire Clustering for Single-cell Sequencing with Iterative Label Propagation and Parallelized Monte Carlo Simulation

arXiv: https://arxiv.org/abs/2103.11802 · HTML: https://mlsanity.com/paper/2103.11802/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 51 references that are in the map.
- First posted on arXiv 22 Mar 2021.

## Builds on (most cited first, 5 of 5)

- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [From Louvain to Leiden: guaranteeing well-connected communities](https://mlsanity.com/paper/1810.08473/) (2018)
- [Selective Inference for Hierarchical Clustering](https://mlsanity.com/paper/2012.02936/) (2020)
- [Diffusion K-means clustering on manifolds: provable exact recovery via semidefinite relaxations](https://mlsanity.com/paper/1903.04416/) (2019)
- [Monte Carlo approximation certificates for k-means clustering](https://mlsanity.com/paper/1710.00956/) (2017)

## Abstract (arXiv)

In the era of single-cell sequencing, there is a growing need to extract insights from data with clustering methods. Here, we introduce Forest Fire Clustering, an efficient and interpretable method for cell-type discovery from single-cell data. Forest Fire Clustering makes minimal prior assumptions and, different from current approaches, calculates a non-parametric posterior probability that each cell is assigned a cell-type label. These posterior distributions allow for the evaluation of a label confidence for each cell and enable the computation of "label entropies," highlighting transitions along developmental trajectories. Furthermore, we show that Forest Fire Clustering can make robust, inductive inferences in an online-learning context and can readily scale to millions of cells. Finally, we demonstrate that our method outperforms state-of-the-art clustering approaches on diverse benchmarks of simulated and experimental data. Overall, Forest Fire Clustering is a useful tool for rare cell type discovery in large-scale single-cell analysis.