# Interpretability of a Deep Learning Model in the Application of Cardiac MRI Segmentation with an ACDC Challenge Dataset

arXiv: https://arxiv.org/abs/2103.08590 · HTML: https://mlsanity.com/paper/2103.08590/

## Key facts

- Cited by 8 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 22 references that are in the map.
- First posted on arXiv 15 Mar 2021.

## Builds on (most cited first, 11 of 11)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Towards A Rigorous Science of Interpretable Machine Learning](https://mlsanity.com/paper/1702.08608/) (2017)
- [Interpretability Beyond Feature Attribution: Quantitative Testing with Concept Activation Vectors (TCAV)](https://mlsanity.com/paper/1711.11279/) (2017)
- [Explanation in Artificial Intelligence: Insights from the Social Sciences](https://mlsanity.com/paper/1706.07269/) (2017)
- [A Survey Of Methods For Explaining Black Box Models](https://mlsanity.com/paper/1802.01933/) (2018)
- [An Exploration of 2D and 3D Deep Learning Techniques for Cardiac MR Image Segmentation](https://mlsanity.com/paper/1709.04496/) (2017)
- [Global and Local Interpretability for Cardiac MRI Classification](https://mlsanity.com/paper/1906.06188/) (2019)
- [Towards Automatic Concept-based Explanations](https://mlsanity.com/paper/1902.03129/) (2019)

## Built on by (most cited first, 8 of 8)

- [Transparency of Deep Neural Networks for Medical Image Analysis: A Review of Interpretability Methods](https://mlsanity.com/paper/2111.02398/) (2021)
- [Explainable Medical Imaging AI Needs Human-Centered Design: Guidelines and Evidence from a Systematic Review](https://mlsanity.com/paper/2112.12596/) (2021)
- [ClaSP -- Parameter-free Time Series Segmentation](https://mlsanity.com/paper/2207.13987/) (2022)
- [Explainable AI (XAI) in Image Segmentation in Medicine, Industry, and Beyond: A Survey](https://mlsanity.com/paper/2405.01636/) (2024)
- [Making Corgis Important for Honeycomb Classification: Adversarial Attacks on Concept-based Explainability Tools](https://mlsanity.com/paper/2110.07120/) (2021)
- [Optimising Knee Injury Detection with Spatial Attention and Validating Localisation Ability](https://mlsanity.com/paper/2108.08136/) (2021)
- [Automated Diagnosis of Cardiovascular Diseases from Cardiac Magnetic Resonance Imaging Using Deep Learning Models: A Review](https://mlsanity.com/paper/2210.14909/) (2022)
- [PULSE: A Unified Multi-Task Architecture for Cardiac Segmentation, Diagnosis, and Few-Shot Cross-Modality Clinical Adaptation](https://mlsanity.com/paper/2512.03848/) (2025)

## Abstract (arXiv)

Cardiac Magnetic Resonance (CMR) is the most effective tool for the assessment and diagnosis of a heart condition, which malfunction is the world's leading cause of death. Software tools leveraging Artificial Intelligence already enhance radiologists and cardiologists in heart condition assessment but their lack of transparency is a problem. This project investigates if it is possible to discover concepts representative for different cardiac conditions from the deep network trained to segment crdiac structures: Left Ventricle (LV), Right Ventricle (RV) and Myocardium (MYO), using explainability methods that enhances classification system by providing the score-based values of qualitative concepts, along with the key performance metrics. With introduction of a need of explanations in GDPR explainability of AI systems is necessary. This study applies Discovering and Testing with Concept Activation Vectors (D-TCAV), an interpretaibilty method to extract underlying features important for cardiac disease diagnosis from MRI data. The method provides a quantitative notion of concept importance for disease classified. In previous studies, the base method is applied to the classification of cardiac disease and provides clinically meaningful explanations for the predictions of a black-box deep learning classifier. This study applies a method extending TCAV with a Discovering phase (D-TCAV) to cardiac MRI analysis. The advantage of the D-TCAV method over the base method is that it is user-independent. The contribution of this study is a novel application of the explainability method D-TCAV for cardiac MRI anlysis. D-TCAV provides a shorter pre-processing time for clinicians than the base method.