# Unsupervised Domain Adaptation Network with Category-Centric Prototype Aligner for Biomedical Image Segmentation

arXiv: https://arxiv.org/abs/2103.02220 · HTML: https://mlsanity.com/paper/2103.02220/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 36 of its 58 references that are in the map.
- First posted on arXiv 3 Mar 2021.

## Builds on (most cited first, 30 of 36)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Domain-Adversarial Training of Neural Networks](https://mlsanity.com/paper/1505.07818/) (2015)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [CyCADA: Cycle-Consistent Adversarial Domain Adaptation](https://mlsanity.com/paper/1711.03213/) (2017)
- [Deep Visual Domain Adaptation: A Survey](https://mlsanity.com/paper/1802.03601/) (2018)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [Deep Domain Confusion: Maximizing for Domain Invariance](https://mlsanity.com/paper/1412.3474/) (2014)
- [Learning to Adapt Structured Output Space for Semantic Segmentation](https://mlsanity.com/paper/1802.10349/) (2018)
- [Semi-supervised Domain Adaptation via Minimax Entropy](https://mlsanity.com/paper/1904.06487/) (2019)
- [Dilated Residual Networks](https://mlsanity.com/paper/1705.09914/) (2017)
- [Multi-Adversarial Domain Adaptation](https://mlsanity.com/paper/1809.02176/) (2018)
- [Generate To Adapt: Aligning Domains using Generative Adversarial Networks](https://mlsanity.com/paper/1704.01705/) (2017)
- [Mind the Class Weight Bias: Weighted Maximum Mean Discrepancy for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1705.00609/) (2017)
- [Transferrable Prototypical Networks for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1904.11227/) (2019)
- [Unsupervised Bidirectional Cross-Modality Adaptation via Deeply Synergistic Image and Feature Alignment for Medical Image Segmentation](https://mlsanity.com/paper/2002.02255/) (2020)
- [Deep learning for cardiac image segmentation: A review](https://mlsanity.com/paper/1911.03723/) (2019)
- [Unsupervised domain adaptation in brain lesion segmentation with adversarial networks](https://mlsanity.com/paper/1612.08894/) (2016)
- [Deep Semantic Segmentation of Natural and Medical Images: A Review](https://mlsanity.com/paper/1910.07655/) (2019)
- [Synergistic Image and Feature Adaptation: Towards Cross-Modality Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/1901.08211/) (2019)
- [No More Discrimination: Cross City Adaptation of Road Scene Segmenters](https://mlsanity.com/paper/1704.08509/) (2017)
- [Cross-domain Detection via Graph-induced Prototype Alignment](https://mlsanity.com/paper/2003.12849/) (2020)
- [Unsupervised Domain Adaptation in Semantic Segmentation: a Review](https://mlsanity.com/paper/2005.10876/) (2020)
- [Unsupervised Person Re-identification: Clustering and Fine-tuning](https://mlsanity.com/paper/1705.10444/) (2017)
- [Transfer Learning for Domain Adaptation in MRI: Application in Brain Lesion Segmentation](https://mlsanity.com/paper/1702.07841/) (2017)

## Built on by (most cited first, 1 of 1)

- [Medical Image Segmentation with Domain Adaptation: A Survey](https://mlsanity.com/paper/2311.01702/) (2023)

## Abstract (arXiv)

With the widespread success of deep learning in biomedical image segmentation, domain shift becomes a critical and challenging problem, as the gap between two domains can severely affect model performance when deployed to unseen data with heterogeneous features. To alleviate this problem, we present a novel unsupervised domain adaptation network, for generalizing models learned from the labeled source domain to the unlabeled target domain for cross-modality biomedical image segmentation. Specifically, our approach consists of two key modules, a conditional domain discriminator~(CDD) and a category-centric prototype aligner~(CCPA). The CDD, extended from conditional domain adversarial networks in classifier tasks, is effective and robust in handling complex cross-modality biomedical images. The CCPA, improved from the graph-induced prototype alignment mechanism in cross-domain object detection, can exploit precise instance-level features through an elaborate prototype representation. In addition, it can address the negative effect of class imbalance via entropy-based loss. Extensive experiments on a public benchmark for the cardiac substructure segmentation task demonstrate that our method significantly improves performance on the target domain.