# MixSearch: Searching for Domain Generalized Medical Image Segmentation Architectures

arXiv: https://arxiv.org/abs/2102.13280 · HTML: https://mlsanity.com/paper/2102.13280/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 41 of its 51 references that are in the map.
- First posted on arXiv 26 Feb 2021.

## Builds on (most cited first, 30 of 41)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [FaceNet: A Unified Embedding for Face Recognition and Clustering](https://mlsanity.com/paper/1503.03832/) (2015)
- [Rethinking Atrous Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1706.05587/) (2017)
- [Searching for MobileNetV3](https://mlsanity.com/paper/1905.02244/) (2019)
- [DARTS: Differentiable Architecture Search](https://mlsanity.com/paper/1806.09055/) (2018)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Neural Architecture Search with Reinforcement Learning](https://mlsanity.com/paper/1611.01578/) (2016)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [ShuffleNet: An Extremely Efficient Convolutional Neural Network for Mobile Devices](https://mlsanity.com/paper/1707.01083/) (2017)
- [Regularized Evolution for Image Classifier Architecture Search](https://mlsanity.com/paper/1802.01548/) (2018)
- [Efficient Neural Architecture Search via Parameter Sharing](https://mlsanity.com/paper/1802.03268/) (2018)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Progressive Neural Architecture Search](https://mlsanity.com/paper/1712.00559/) (2017)
- [Deep Layer Aggregation](https://mlsanity.com/paper/1707.06484/) (2017)
- [Transfusion: Understanding Transfer Learning for Medical Imaging](https://mlsanity.com/paper/1902.07208/) (2019)
- [UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentation](https://mlsanity.com/paper/2004.08790/) (2020)
- [Auto-DeepLab: Hierarchical Neural Architecture Search for Semantic Image Segmentation](https://mlsanity.com/paper/1901.02985/) (2019)
- [Progressive Differentiable Architecture Search: Bridging the Depth Gap between Search and Evaluation](https://mlsanity.com/paper/1904.12760/) (2019)
- [MultiResUNet : Rethinking the U-Net Architecture for Multimodal Biomedical Image Segmentation](https://mlsanity.com/paper/1902.04049/) (2019)

## Built on by (most cited first, 4 of 4)

- [β-DARTS: Beta-Decay Regularization for Differentiable Architecture Search](https://mlsanity.com/paper/2203.01665/) (2022)
- [Lambda-DARTS: Mitigating Performance Collapse by Harmonizing Operation Selection among Cells](https://mlsanity.com/paper/2210.07998/) (2022)
- [β-DARTS++: Bi-level Regularization for Proxy-robust Differentiable Architecture Search](https://mlsanity.com/paper/2301.06393/) (2023)
- [SSHNN: Semi-Supervised Hybrid NAS Network for Echocardiographic Image Segmentation](https://mlsanity.com/paper/2309.04672/) (2023)

## Abstract (arXiv)

Considering the scarcity of medical data, most datasets in medical image analysis are an order of magnitude smaller than those of natural images. However, most Network Architecture Search (NAS) approaches in medical images focused on specific datasets and did not take into account the generalization ability of the learned architectures on unseen datasets as well as different domains. In this paper, we address this point by proposing to search for generalizable U-shape architectures on a composited dataset that mixes medical images from multiple segmentation tasks and domains creatively, which is named MixSearch. Specifically, we propose a novel approach to mix multiple small-scale datasets from multiple domains and segmentation tasks to produce a large-scale dataset. Then, a novel weaved encoder-decoder structure is designed to search for a generalized segmentation network in both cell-level and network-level. The network produced by the proposed MixSearch framework achieves state-of-the-art results compared with advanced encoder-decoder networks across various datasets.