# Interpretative Computer-aided Lung Cancer Diagnosis: from Radiology Analysis to Malignancy Evaluation

arXiv: https://arxiv.org/abs/2102.10919 · HTML: https://mlsanity.com/paper/2102.10919/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 23 of its 33 references that are in the map.
- First posted on arXiv 22 Feb 2021.

## Builds on (most cited first, 23 of 23)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Non-local Neural Networks](https://mlsanity.com/paper/1711.07971/) (2017)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Grad-CAM++: Improved Visual Explanations for Deep Convolutional Networks](https://mlsanity.com/paper/1710.11063/) (2017)
- [Score-CAM: Score-Weighted Visual Explanations for Convolutional Neural Networks](https://mlsanity.com/paper/1910.01279/) (2019)
- [GCNet: Non-local Networks Meet Squeeze-Excitation Networks and Beyond](https://mlsanity.com/paper/1904.11492/) (2019)
- [Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge](https://mlsanity.com/paper/1612.08012/) (2016)
- [Evaluate the Malignancy of Pulmonary Nodules Using the 3D Deep Leaky Noisy-or Network](https://mlsanity.com/paper/1711.08324/) (2017)
- [DeepLung: Deep 3D Dual Path Nets for Automated Pulmonary Nodule Detection and Classification](https://mlsanity.com/paper/1801.09555/) (2018)
- [A 3D Probabilistic Deep Learning System for Detection and Diagnosis of Lung Cancer Using Low-Dose CT Scans](https://mlsanity.com/paper/1902.03233/) (2019)
- [Joint Learning for Pulmonary Nodule Segmentation, Attributes and Malignancy Prediction](https://mlsanity.com/paper/1802.03584/) (2018)
- [Risk Stratification of Lung Nodules Using 3D CNN-Based Multi-task Learning](https://mlsanity.com/paper/1704.08797/) (2017)
- [TumorNet: Lung Nodule Characterization Using Multi-View Convolutional Neural Network with Gaussian Process](https://mlsanity.com/paper/1703.00645/) (2017)
- [Lung Nodule Classification using Deep Local-Global Networks](https://mlsanity.com/paper/1904.10126/) (2019)
- [Integration of Convolutional Neural Networks for Pulmonary Nodule Malignancy Assessment in a Lung Cancer Classification Pipeline](https://mlsanity.com/paper/1912.08679/) (2019)

## Abstract (arXiv)

Background and Objective:Computer-aided diagnosis (CAD) systems promote diagnosis effectiveness and alleviate pressure of radiologists. A CAD system for lung cancer diagnosis includes nodule candidate detection and nodule malignancy evaluation. Recently, deep learning-based pulmonary nodule detection has reached satisfactory performance ready for clinical application. However, deep learning-based nodule malignancy evaluation depends on heuristic inference from low-dose computed tomography volume to malignant probability, which lacks clinical cognition. Methods:In this paper, we propose a joint radiology analysis and malignancy evaluation network (R2MNet) to evaluate the pulmonary nodule malignancy via radiology characteristics analysis. Radiological features are extracted as channel descriptor to highlight specific regions of the input volume that are critical for nodule malignancy evaluation. In addition, for model explanations, we propose channel-dependent activation mapping to visualize the features and shed light on the decision process of deep neural network. Results:Experimental results on the LIDC-IDRI dataset demonstrate that the proposed method achieved area under curve of 96.27% on nodule radiology analysis and AUC of 97.52% on nodule malignancy evaluation. In addition, explanations of CDAM features proved that the shape and density of nodule regions were two critical factors that influence a nodule to be inferred as malignant, which conforms with the diagnosis cognition of experienced radiologists. Conclusion:Incorporating radiology analysis with nodule malignant evaluation, the network inference process conforms to the diagnostic procedure of radiologists and increases the confidence of evaluation results. Besides, model interpretation with CDAM features shed light on the regions which DNNs focus on when they estimate nodule malignancy probabilities.