# BEDS: Bagging ensemble deep segmentation for nucleus segmentation with testing stage stain augmentation

arXiv: https://arxiv.org/abs/2102.08990 · HTML: https://mlsanity.com/paper/2102.08990/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 11 references that are in the map.
- First posted on arXiv 17 Feb 2021.

## Builds on (most cited first, 6 of 6)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [No New-Net](https://mlsanity.com/paper/1809.10483/) (2018)
- [Ensembles of Multiple Models and Architectures for Robust Brain Tumour Segmentation](https://mlsanity.com/paper/1711.01468/) (2017)
- [Dataset of Segmented Nuclei in Hematoxylin and Eosin Stained Histopathology Images of 10 Cancer Types](https://mlsanity.com/paper/2002.07913/) (2020)

## Built on by (most cited first, 3 of 3)

- [Segment Anything Model (SAM) for Digital Pathology: Assess Zero-shot Segmentation on Whole Slide Imaging](https://mlsanity.com/paper/2304.04155/) (2023)
- [All-in-SAM: from Weak Annotation to Pixel-wise Nuclei Segmentation with Prompt-based Finetuning](https://mlsanity.com/paper/2307.00290/) (2023)
- [Two layer Ensemble of Deep Learning Models for Medical Image Segmentation](https://mlsanity.com/paper/2104.04809/) (2021)

## Abstract (arXiv)

Reducing outcome variance is an essential task in deep learning based medical image analysis. Bootstrap aggregating, also known as bagging, is a canonical ensemble algorithm for aggregating weak learners to become a strong learner. Random forest is one of the most powerful machine learning algorithms before deep learning era, whose superior performance is driven by fitting bagged decision trees (weak learners). Inspired by the random forest technique, we propose a simple bagging ensemble deep segmentation (BEDs) method to train multiple U-Nets with partial training data to segment dense nuclei on pathological images. The contributions of this study are three-fold: (1) developing a self-ensemble learning framework for nucleus segmentation; (2) aggregating testing stage augmentation with self-ensemble learning; and (3) elucidating the idea that self-ensemble and testing stage stain augmentation are complementary strategies for a superior segmentation performance. Implementation Detail: https://github.com/xingli1102/BEDs.