# Model Adaptation for Image Reconstruction using Generalized Stein's Unbiased Risk Estimator

arXiv: https://arxiv.org/abs/2102.00047 · HTML: https://mlsanity.com/paper/2102.00047/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 18 references that are in the map.
- First posted on arXiv 29 Jan 2021.

## Builds on (most cited first, 10 of 10)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Deep Image Prior](https://mlsanity.com/paper/1711.10925/) (2017)
- [MoDL: Model Based Deep Learning Architecture for Inverse Problems](https://mlsanity.com/paper/1712.02862/) (2017)
- [Learning a Variational Network for Reconstruction of Accelerated MRI Data](https://mlsanity.com/paper/1704.00447/) (2017)
- [A Deep Cascade of Convolutional Neural Networks for Dynamic MR Image Reconstruction](https://mlsanity.com/paper/1704.02422/) (2017)
- [A deep convolutional neural network using directional wavelets for low-dose X-ray CT reconstruction](https://mlsanity.com/paper/1610.09736/) (2016)
- [Compressed Sensing MRI Reconstruction using a Generative Adversarial Network with a Cyclic Loss](https://mlsanity.com/paper/1709.00753/) (2017)
- [Unsupervised Learning with Stein's Unbiased Risk Estimator](https://mlsanity.com/paper/1805.10531/) (2018)
- [Sigma-net: Systematic Evaluation of Iterative Deep Neural Networks for Fast Parallel MR Image Reconstruction](https://mlsanity.com/paper/1912.09278/) (2019)
- [High-Fidelity Accelerated MRI Reconstruction by Scan-Specific Fine-Tuning of Physics-Based Neural Networks](https://mlsanity.com/paper/2005.05550/) (2020)

## Built on by (most cited first, 4 of 4)

- [Adaptive Diffusion Priors for Accelerated MRI Reconstruction](https://mlsanity.com/paper/2207.05876/) (2022)
- [Unsupervised MRI Reconstruction via Zero-Shot Learned Adversarial Transformers](https://mlsanity.com/paper/2105.08059/) (2021)
- [Federated Learning of Generative Image Priors for MRI Reconstruction](https://mlsanity.com/paper/2202.04175/) (2022)
- [Denoising via Repainting: an image denoising method using layer wise medical image repainting](https://mlsanity.com/paper/2503.08094/) (2025)

## Abstract (arXiv)

Deep learning image reconstruction algorithms often suffer from model mismatches when the acquisition scheme differs significantly from the forward model used during training. We introduce a Generalized Stein's Unbiased Risk Estimate (GSURE) loss metric to adapt the network to the measured k-space data and minimize model misfit impact. Unlike current methods that rely on the mean square error in kspace, the proposed metric accounts for noise in the measurements. This makes the approach less vulnerable to overfitting, thus offering improved reconstruction quality compared to schemes that rely on mean-square error. This approach may be useful to rapidly adapt pre-trained models to new acquisition settings (e.g., multi-site) and different contrasts than training data