# Cross Chest Graph for Disease Diagnosis with Structural Relational Reasoning

arXiv: https://arxiv.org/abs/2101.08992 · HTML: https://mlsanity.com/paper/2101.08992/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 17 of its 30 references that are in the map.
- First posted on arXiv 22 Jan 2021.

## Builds on (most cited first, 17 of 17)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [SSD: Single Shot MultiBox Detector](https://mlsanity.com/paper/1512.02325/) (2015)
- [Fast R-CNN](https://mlsanity.com/paper/1504.08083/) (2015)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Deep Networks with Stochastic Depth](https://mlsanity.com/paper/1603.09382/) (2016)
- [Spatial Pyramid Pooling in Deep Convolutional Networks for Visual Recognition](https://mlsanity.com/paper/1406.4729/) (2014)
- [Net2Net: Accelerating Learning via Knowledge Transfer](https://mlsanity.com/paper/1511.05641/) (2015)
- [Knowledge-driven Encode, Retrieve, Paraphrase for Medical Image Report Generation](https://mlsanity.com/paper/1903.10122/) (2019)
- [Thoracic Disease Identification and Localization with Limited Supervision](https://mlsanity.com/paper/1711.06373/) (2017)
- [Diagnose like a Radiologist: Attention Guided Convolutional Neural Network for Thorax Disease Classification](https://mlsanity.com/paper/1801.09927/) (2018)
- [Contralaterally Enhanced Networks for Thoracic Disease Detection](https://mlsanity.com/paper/2010.04483/) (2020)
- [Learning what to look in chest X-rays with a recurrent visual attention model](https://mlsanity.com/paper/1701.06452/) (2017)

## Built on by (most cited first, 4 of 4)

- [Self-eXplainable AI for Medical Image Analysis: A Survey and New Outlooks](https://mlsanity.com/paper/2410.02331/) (2024)
- [Expert Uncertainty and Severity Aware Chest X-Ray Classification by Multi-Relationship Graph Learning](https://mlsanity.com/paper/2309.03331/) (2023)
- [GREN: Graph-Regularized Embedding Network for Weakly-Supervised Disease Localization in X-ray Images](https://mlsanity.com/paper/2107.06442/) (2021)
- [CLARiTy: A Vision Transformer for Multi-Label Classification and Weakly-Supervised Localization of Chest X-ray Pathologies](https://mlsanity.com/paper/2512.16700/) (2025)

## Abstract (arXiv)

Locating lesions is important in the computer-aided diagnosis of X-ray images. However, box-level annotation is time-consuming and laborious. How to locate lesions accurately with few, or even without careful annotations is an urgent problem. Although several works have approached this problem with weakly-supervised methods, the performance needs to be improved. One obstacle is that general weakly-supervised methods have failed to consider the characteristics of X-ray images, such as the highly-structural attribute. We therefore propose the Cross-chest Graph (CCG), which improves the performance of automatic lesion detection by imitating doctor's training and decision-making process. CCG models the intra-image relationship between different anatomical areas by leveraging the structural information to simulate the doctor's habit of observing different areas. Meanwhile, the relationship between any pair of images is modeled by a knowledge-reasoning module to simulate the doctor's habit of comparing multiple images. We integrate intra-image and inter-image information into a unified end-to-end framework. Experimental results on the NIH Chest-14 database (112,120 frontal-view X-ray images with 14 diseases) demonstrate that the proposed method achieves state-of-the-art performance in weakly-supervised localization of lesions by absorbing professional knowledge in the medical field.