# Adversarial Sample Enhanced Domain Adaptation: A Case Study on Predictive Modeling with Electronic Health Records

arXiv: https://arxiv.org/abs/2101.04853 · HTML: https://mlsanity.com/paper/2101.04853/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 37 references that are in the map.
- First posted on arXiv 13 Jan 2021.

## Builds on (most cited first, 15 of 15)

- [Explaining and Harnessing Adversarial Examples](https://mlsanity.com/paper/1412.6572/) (2014)
- [Towards Deep Learning Models Resistant to Adversarial Attacks](https://mlsanity.com/paper/1706.06083/) (2017)
- [Domain-Adversarial Training of Neural Networks](https://mlsanity.com/paper/1505.07818/) (2015)
- [Adversarial examples in the physical world](https://mlsanity.com/paper/1607.02533/) (2016)
- [Theoretically Principled Trade-off between Robustness and Accuracy](https://mlsanity.com/paper/1901.08573/) (2019)
- [A Comprehensive Survey on Transfer Learning](https://mlsanity.com/paper/1911.02685/) (2019)
- [Adversarial Examples Are Not Bugs, They Are Features](https://mlsanity.com/paper/1905.02175/) (2019)
- [Robustness May Be at Odds with Accuracy](https://mlsanity.com/paper/1805.12152/) (2018)
- [Multitask learning and benchmarking with clinical time series data](https://mlsanity.com/paper/1703.07771/) (2017)
- [MMA Training: Direct Input Space Margin Maximization through Adversarial Training](https://mlsanity.com/paper/1812.02637/) (2018)
- [Deep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis](https://mlsanity.com/paper/1706.03446/) (2017)
- [Is Robustness the Cost of Accuracy? -- A Comprehensive Study on the Robustness of 18 Deep Image Classification Models](https://mlsanity.com/paper/1808.01688/) (2018)
- [An introduction to domain adaptation and transfer learning](https://mlsanity.com/paper/1812.11806/) (2018)
- [Discrete Adversarial Attacks and Submodular Optimization with Applications to Text Classification](https://mlsanity.com/paper/1812.00151/) (2018)
- [Dynamic Prediction of ICU Mortality Risk Using Domain Adaptation](https://mlsanity.com/paper/1912.10080/) (2019)

## Abstract (arXiv)

With the successful adoption of machine learning on electronic health records (EHRs), numerous computational models have been deployed to address a variety of clinical problems. However, due to the heterogeneity of EHRs, models trained on different patient groups suffer from poor generalizability. How to mitigate domain shifts between the source patient group where the model is built upon and the target one where the model will be deployed becomes a critical issue. In this paper, we propose a data augmentation method to facilitate domain adaptation, which leverages knowledge from the source patient group when training model on the target one. Specifically, adversarially generated samples are used during domain adaptation to fill the generalization gap between the two patient groups. The proposed method is evaluated by a case study on different predictive modeling tasks on MIMIC-III EHR dataset. Results confirm the effectiveness of our method and the generality on different tasks.