# Learning Tubule-Sensitive CNNs for Pulmonary Airway and Artery-Vein Segmentation in CT

arXiv: https://arxiv.org/abs/2012.05767 · HTML: https://mlsanity.com/paper/2012.05767/

## Key facts

- Cited by 28 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 10 Dec 2020.

## Built on by (most cited first, 28 of 28)

- [Automatic airway segmentation from Computed Tomography using robust and efficient 3-D convolutional neural networks](https://mlsanity.com/paper/2103.16328/) (2021)
- [NaviAirway: a Bronchiole-sensitive Deep Learning-based Airway Segmentation Pipeline](https://mlsanity.com/paper/2203.04294/) (2022)
- [Human Treelike Tubular Structure Segmentation: A Comprehensive Review and Future Perspectives](https://mlsanity.com/paper/2207.11203/) (2022)
- [Two-stage Contextual Transformer-based Convolutional Neural Network for Airway Extraction from CT Images](https://mlsanity.com/paper/2212.07651/) (2022)
- [AeroPath: An airway segmentation benchmark dataset with challenging pathology](https://mlsanity.com/paper/2311.01138/) (2023)
- [Multi-site, Multi-domain Airway Tree Modeling (ATM'22): A Public Benchmark for Pulmonary Airway Segmentation](https://mlsanity.com/paper/2303.05745/) (2023)
- [Deep learning-driven pulmonary artery and vein segmentation reveals demography-associated vasculature anatomical differences](https://mlsanity.com/paper/2404.07671/) (2024)
- [Hepatic vessel segmentation based on 3D swin-transformer with inductive biased multi-head self-attention](https://mlsanity.com/paper/2111.03368/) (2021)
- [What Makes for Automatic Reconstruction of Pulmonary Segments](https://mlsanity.com/paper/2207.03078/) (2022)
- [Accurate Airway Tree Segmentation in CT Scans via Anatomy-aware Multi-class Segmentation and Topology-guided Iterative Learning](https://mlsanity.com/paper/2306.09116/) (2023)
- [Topology Repairing of Disconnected Pulmonary Airways and Vessels: Baselines and a Dataset](https://mlsanity.com/paper/2306.07089/) (2023)
- [Efficient Anatomical Labeling of Pulmonary Tree Structures via Deep Point-Graph Representation-based Implicit Fields](https://mlsanity.com/paper/2309.17329/) (2023)
- [Intensity Confusion Matters: An Intensity-Distance Guided Loss for Bronchus Segmentation](https://mlsanity.com/paper/2406.16150/) (2024)
- [BCNet: Bronchus Classification via Structure Guided Representation Learning](https://mlsanity.com/paper/2205.06947/) (2022)
- [Coarse-to-fine Airway Segmentation Using Multi information Fusion Network and CNN-based Region Growing](https://mlsanity.com/paper/2102.12755/) (2021)
- [Label Refinement Network from Synthetic Error Augmentation for Medical Image Segmentation](https://mlsanity.com/paper/2209.06353/) (2022)
- [GDDS: Pulmonary Bronchioles Segmentation with Group Deep Dense Supervision](https://mlsanity.com/paper/2303.09212/) (2023)
- [HarmonySeg: Tubular Structure Segmentation with Deep-Shallow Feature Fusion and Growth-Suppression Balanced Loss](https://mlsanity.com/paper/2504.07827/) (2025)
- [Extraction of Pulmonary Airway in CT Scans Using Deep Fully Convolutional Networks](https://mlsanity.com/paper/2208.07202/) (2022)
- [Differentiable Topology-Preserved Distance Transform for Pulmonary Airway Segmentation](https://mlsanity.com/paper/2209.08355/) (2022)
- [Progressive Curriculum Learning with Scale-Enhanced U-Net for Continuous Airway Segmentation](https://mlsanity.com/paper/2410.18456/) (2024)
- [Relationship between pulmonary nodule malignancy and surrounding pleurae, airways and vessels: a quantitative study using the public LIDC-IDRI dataset](https://mlsanity.com/paper/2106.12991/) (2021)
- [Automatic Pulmonary Artery-Vein Separation in CT Images using Twin-Pipe Network and Topology Reconstruction](https://mlsanity.com/paper/2103.11736/) (2021)
- [Skeleton Supervised Airway Segmentation](https://mlsanity.com/paper/2403.06510/) (2024)
- [Template-Guided Reconstruction of Pulmonary Segments with Neural Implicit Functions](https://mlsanity.com/paper/2505.08919/) (2025)
- [Airway Segmentation Network for Enhanced Tubular Feature Extraction](https://mlsanity.com/paper/2507.06581/) (2025)
- [A Self-training Framework for Semi-supervised Pulmonary Vessel Segmentation and Its Application in COPD](https://mlsanity.com/paper/2507.19074/) (2025)
- [Learning Topology-Aware Implicit Field for Unified Pulmonary Tree Modeling with Incomplete Topological Supervision](https://mlsanity.com/paper/2602.02186/) (2026)

## Abstract (arXiv)

Training convolutional neural networks (CNNs) for segmentation of pulmonary airway, artery, and vein is challenging due to sparse supervisory signals caused by the severe class imbalance between tubular targets and background. We present a CNNs-based method for accurate airway and artery-vein segmentation in non-contrast computed tomography. It enjoys superior sensitivity to tenuous peripheral bronchioles, arterioles, and venules. The method first uses a feature recalibration module to make the best use of features learned from the neural networks. Spatial information of features is properly integrated to retain relative priority of activated regions, which benefits the subsequent channel-wise recalibration. Then, attention distillation module is introduced to reinforce representation learning of tubular objects. Fine-grained details in high-resolution attention maps are passing down from one layer to its previous layer recursively to enrich context. Anatomy prior of lung context map and distance transform map is designed and incorporated for better artery-vein differentiation capacity. Extensive experiments demonstrated considerable performance gains brought by these components. Compared with state-of-the-art methods, our method extracted much more branches while maintaining competitive overall segmentation performance. Codes and models are available at http://www.pami.sjtu.edu.cn/News/56