# Multiply robust estimation of causal effects under principal ignorability

arXiv: https://arxiv.org/abs/2012.01615 · HTML: https://mlsanity.com/paper/2012.01615/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 3 Dec 2020.

## Built on by (most cited first, 9 of 9)

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- [Evaluating and Learning Optimal Dynamic Treatment Regimes under Truncation by Death](https://mlsanity.com/paper/2510.07501/) (2025)
- [Identification and multiply robust estimation in causal mediation analysis across principal strata](https://mlsanity.com/paper/2304.10025/) (2023)
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- [Integrating RCTs, RWD, AI/ML and Statistics: Next-Generation Evidence Synthesis](https://mlsanity.com/paper/2511.19735/) (2025)

## Abstract (arXiv)

Causal inference concerns not only the average effect of the treatment on the outcome but also the underlying mechanism through an intermediate variable of interest. Principal stratification characterizes such a mechanism by targeting subgroup causal effects within principal strata, which are defined by the joint potential values of an intermediate variable. Due to the fundamental problem of causal inference, principal strata are inherently latent, rendering it challenging to identify and estimate subgroup effects within them. A line of research leverages the principal ignorability assumption that the latent principal strata are mean independent of the potential outcomes conditioning on the observed covariates. Under principal ignorability, we derive various nonparametric identification formulas for causal effects within principal strata in observational studies, which motivate estimators relying on the correct specifications of different parts of the observed-data distribution. Appropriately combining these estimators yields triply robust estimators for the causal effects within principal strata. These triply robust estimators are consistent if two of the treatment, intermediate variable, and outcome models are correctly specified, and moreover, they are locally efficient if all three models are correctly specified. We show that these estimators arise naturally from either the efficient influence functions in the semiparametric theory or the model-assisted estimators in the survey sampling theory. We evaluate different estimators based on their finite-sample performance through simulation and apply them to two observational studies.