# Deep Learning-Based Grading of Ductal Carcinoma In Situ in Breast Histopathology Images

arXiv: https://arxiv.org/abs/2010.03244 · HTML: https://mlsanity.com/paper/2010.03244/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 7 Oct 2020.

## Built on by (most cited first, 3 of 3)

- [Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions](https://mlsanity.com/paper/2304.06662/) (2023)
- [WSI-SAM: Multi-resolution Segment Anything Model (SAM) for histopathology whole-slide images](https://mlsanity.com/paper/2403.09257/) (2024)
- [PathoPainter: Augmenting Histopathology Segmentation via Tumor-aware Inpainting](https://mlsanity.com/paper/2503.04634/) (2025)

## Abstract (arXiv)

Ductal carcinoma in situ (DCIS) is a non-invasive breast cancer that can progress into invasive ductal carcinoma (IDC). Studies suggest DCIS is often overtreated since a considerable part of DCIS lesions may never progress into IDC. Lower grade lesions have a lower progression speed and risk, possibly allowing treatment de-escalation. However, studies show significant inter-observer variation in DCIS grading. Automated image analysis may provide an objective solution to address high subjectivity of DCIS grading by pathologists. In this study, we developed a deep learning-based DCIS grading system. It was developed using the consensus DCIS grade of three expert observers on a dataset of 1186 DCIS lesions from 59 patients. The inter-observer agreement, measured by quadratic weighted Cohen's kappa, was used to evaluate the system and compare its performance to that of expert observers. We present an analysis of the lesion-level and patient-level inter-observer agreement on an independent test set of 1001 lesions from 50 patients. The deep learning system (dl) achieved on average slightly higher inter-observer agreement to the observers (o1, o2 and o3) (kappao1,dl=0.81, kappao2,dl=0.53, kappao3,dl=0.40) than the observers amongst each other (kappao1,o2=0.58, kappao1,o3=0.50, kappao2,o3=0.42) at the lesion-level. At the patient-level, the deep learning system achieved similar agreement to the observers (kappao1,dl=0.77, kappao2,dl=0.75, kappao3,dl=0.70) as the observers amongst each other (kappao1,o2=0.77, kappao1,o3=0.75, kappao2,o3=0.72). In conclusion, we developed a deep learning-based DCIS grading system that achieved a performance similar to expert observers. We believe this is the first automated system that could assist pathologists by providing robust and reproducible second opinions on DCIS grade.