# Unsupervised MRI Super-Resolution Using Deep External Learning and Guided Residual Dense Network with Multimodal Image Priors

arXiv: https://arxiv.org/abs/2008.11921 · HTML: https://mlsanity.com/paper/2008.11921/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 27 Aug 2020.

## Built on by (most cited first, 4 of 4)

- [MRI Super-Resolution with Deep Learning: A Comprehensive Survey](https://mlsanity.com/paper/2511.16854/) (2025)
- [Unsupervised Representation Learning for 3D MRI Super Resolution with Degradation Adaptation](https://mlsanity.com/paper/2205.06891/) (2022)
- [VoDaSuRe: A Large-Scale Dataset Revealing Domain Shift in Volumetric Super-Resolution](https://mlsanity.com/paper/2603.23153/) (2026)
- [CEM-TUDASR: Computationally efficient multi-modality transformer based unsupervised domain adaptive super-resolution approach](https://mlsanity.com/paper/2609.11201/) (2026)

## Abstract (arXiv)

Deep learning techniques have led to state-of-the-art image super resolution with natural images. Normally, pairs of high-resolution and low-resolution images are used to train the deep learning models. These techniques have also been applied to medical image super-resolution. The characteristics of medical images differ significantly from natural images in several ways. First, it is difficult to obtain high-resolution images for training in real clinical applications due to the limitations of imaging systems and clinical requirements. Second, other modal high-resolution images are available (e.g., high-resolution T1-weighted images are available for enhancing low-resolution T2-weighted images). In this paper, we propose an unsupervised image super-resolution technique based on simple prior knowledge of the human anatomy. This technique does not require target T2WI high-resolution images for training. Furthermore, we present a guided residual dense network, which incorporates a residual dense network with a guided deep convolutional neural network for enhancing the resolution of low-resolution images by referring to different modal high-resolution images of the same subject. Experiments on a publicly available brain MRI database showed that our proposed method achieves better performance than the state-of-the-art methods.