# Multi-level colonoscopy malignant tissue detection with adversarial CAC-UNet

arXiv: https://arxiv.org/abs/2006.15954 · HTML: https://mlsanity.com/paper/2006.15954/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 29 Jun 2020.

## Built on by (most cited first, 6 of 6)

- [Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides](https://mlsanity.com/paper/2112.02222/) (2021)
- [OCELOT: Overlapped Cell on Tissue Dataset for Histopathology](https://mlsanity.com/paper/2303.13110/) (2023)
- [Colorectal Cancer Segmentation using Atrous Convolution and Residual Enhanced UNet](https://mlsanity.com/paper/2103.09289/) (2021)
- [Enhancing Weakly-Supervised Histopathology Image Segmentation with Knowledge Distillation on MIL-Based Pseudo-Labels](https://mlsanity.com/paper/2407.10274/) (2024)
- [SAGE: Shape-Adapting Gated Experts for Adaptive Histopathology Image Segmentation](https://mlsanity.com/paper/2511.18493/) (2025)
- [MedGEN-Bench: A Contextually Entangled Benchmark for Open-ended Multimodal Medical Generation](https://mlsanity.com/paper/2511.13135/) (2025)

## Abstract (arXiv)

The automatic and objective medical diagnostic model can be valuable to achieve early cancer detection, and thus reducing the mortality rate. In this paper, we propose a highly efficient multi-level malignant tissue detection through the designed adversarial CAC-UNet. A patch-level model with a pre-prediction strategy and a malignancy area guided label smoothing is adopted to remove the negative WSIs, with which to lower the risk of false positive detection. For the selected key patches by multi-model ensemble, an adversarial context-aware and appearance consistency UNet (CAC-UNet) is designed to achieve robust segmentation. In CAC-UNet, mirror designed discriminators are able to seamlessly fuse the whole feature maps of the skillfully designed powerful backbone network without any information loss. Besides, a mask prior is further added to guide the accurate segmentation mask prediction through an extra mask-domain discriminator. The proposed scheme achieves the best results in MICCAI DigestPath2019 challenge on colonoscopy tissue segmentation and classification task. The full implementation details and the trained models are available at https://github.com/Raykoooo/CAC-UNet.