# Machine learning in cardiovascular flows modeling: Predicting arterial blood pressure from non-invasive 4D flow MRI data using physics-informed neural networks

arXiv: https://arxiv.org/abs/1905.04817 · HTML: https://mlsanity.com/paper/1905.04817/

## Key facts

- Cited by 76 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 13 May 2019.

## Built on by (most cited first, 30 of 76)

- [Scientific Machine Learning through Physics-Informed Neural Networks: Where we are and What's next](https://mlsanity.com/paper/2201.05624/) (2022)
- [Learning the solution operator of parametric partial differential equations with physics-informed DeepOnets](https://mlsanity.com/paper/2103.10974/) (2021)
- [Physics-informed neural networks (PINNs) for fluid mechanics: A review](https://mlsanity.com/paper/2105.09506/) (2021)
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- [Respecting causality is all you need for training physics-informed neural networks](https://mlsanity.com/paper/2203.07404/) (2022)
- [Efficient training of physics-informed neural networks via importance sampling](https://mlsanity.com/paper/2104.12325/) (2021)
- [PhyCRNet: Physics-informed Convolutional-Recurrent Network for Solving Spatiotemporal PDEs](https://mlsanity.com/paper/2106.14103/) (2021)
- [CAN-PINN: A Fast Physics-Informed Neural Network Based on Coupled-Automatic-Numerical Differentiation Method](https://mlsanity.com/paper/2110.15832/) (2021)
- [Physics-Informed Machine Learning: A Survey on Problems, Methods and Applications](https://mlsanity.com/paper/2211.08064/) (2022)
- [Long-time integration of parametric evolution equations with physics-informed DeepONets](https://mlsanity.com/paper/2106.05384/) (2021)
- [From PINNs to PIKANs: Recent Advances in Physics-Informed Machine Learning](https://mlsanity.com/paper/2410.13228/) (2024)
- [Encoding physics to learn reaction-diffusion processes](https://mlsanity.com/paper/2106.04781/) (2021)
- [A unified scalable framework for causal sweeping strategies for Physics-Informed Neural Networks (PINNs) and their temporal decompositions](https://mlsanity.com/paper/2302.14227/) (2023)
- [Machine Learning in Aerodynamic Shape Optimization](https://mlsanity.com/paper/2202.07141/) (2022)
- [Physics and Equality Constrained Artificial Neural Networks: Application to Forward and Inverse Problems with Multi-fidelity Data Fusion](https://mlsanity.com/paper/2109.14860/) (2021)
- [Simulating progressive intramural damage leading to aortic dissection using an operator-regression neural network](https://mlsanity.com/paper/2108.11985/) (2021)
- [Physics-informed neural networks for the shallow-water equations on the sphere](https://mlsanity.com/paper/2104.00615/) (2021)
- [Unveiling the optimization process of Physics Informed Neural Networks: How accurate and competitive can PINNs be?](https://mlsanity.com/paper/2405.04230/) (2024)
- [Physics-Informed Computer Vision: A Review and Perspectives](https://mlsanity.com/paper/2305.18035/) (2023)
- [Physics-Guided, Physics-Informed, and Physics-Encoded Neural Networks in Scientific Computing](https://mlsanity.com/paper/2211.07377/) (2022)
- [Deep Learning in Deterministic Computational Mechanics](https://mlsanity.com/paper/2309.15421/) (2023)
- [Learning Reduced-Order Models for Cardiovascular Simulations with Graph Neural Networks](https://mlsanity.com/paper/2303.07310/) (2023)
- [Investigating and Mitigating Failure Modes in Physics-informed Neural Networks (PINNs)](https://mlsanity.com/paper/2209.09988/) (2022)
- [On the Limitations of Physics-informed Deep Learning: Illustrations Using First Order Hyperbolic Conservation Law-based Traffic Flow Models](https://mlsanity.com/paper/2302.12337/) (2023)
- [Gaussian processes meet NeuralODEs: A Bayesian framework for learning the dynamics of partially observed systems from scarce and noisy data](https://mlsanity.com/paper/2103.03385/) (2021)
- [Viscoelastic Constitutive Artificial Neural Networks (vCANNs) - a framework for data-driven anisotropic nonlinear finite viscoelasticity](https://mlsanity.com/paper/2303.12164/) (2023)
- [Learning Only On Boundaries: a Physics-Informed Neural operator for Solving Parametric Partial Differential Equations in Complex Geometries](https://mlsanity.com/paper/2308.12939/) (2023)
- [VS-PINN: A fast and efficient training of physics-informed neural networks using variable-scaling methods for solving PDEs with stiff behavior](https://mlsanity.com/paper/2406.06287/) (2024)
- [Physics-constrained Deep Learning for Robust Inverse ECG Modeling](https://mlsanity.com/paper/2107.12780/) (2021)

## Abstract (arXiv)

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on large patient-specific topologies of systemic arterial networks and return detailed predictions on flow patterns, wall shear stresses, and pulse wave propagation. However, their success heavily relies on tedious pre-processing and calibration procedures that typically induce a significant computational cost, thus hampering their clinical applicability. In this work we put forth a machine learning framework that enables the seamless synthesis of non-invasive in-vivo measurement techniques and computational flow dynamics models derived from first physical principles. We illustrate this new paradigm by showing how one-dimensional models of pulsatile flow can be used to constrain the output of deep neural networks such that their predictions satisfy the conservation of mass and momentum principles. Once trained on noisy and scattered clinical data of flow and wall displacement, these networks can return physically consistent predictions for velocity, pressure and wall displacement pulse wave propagation, all without the need to employ conventional simulators. A simple post-processing of these outputs can also provide a cheap and effective way for estimating Windkessel model parameters that are required for the calibration of traditional computational models. The effectiveness of the proposed techniques is demonstrated through a series of prototype benchmarks, as well as a realistic clinical case involving in-vivo measurements near the aorta/carotid bifurcation of a healthy human subject.