# Classification of EEG-Based Brain Connectivity Networks in Schizophrenia Using a Multi-Domain Connectome Convolutional Neural Network

arXiv: https://arxiv.org/abs/1903.08858 · HTML: https://mlsanity.com/paper/1903.08858/

## Key facts

- Cited by 11 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 21 Mar 2019.

## Built on by (most cited first, 11 of 11)

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- [An Explainable Deep Learning-Based Method For Schizophrenia Diagnosis Using Generative Data-Augmentation](https://mlsanity.com/paper/2310.16867/) (2023)
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- [Novel EEG based Schizophrenia Detection with IoMT Framework for Smart Healthcare](https://mlsanity.com/paper/2111.11298/) (2021)
- [Empowering Precision Medicine: AI-Driven Schizophrenia Diagnosis via EEG Signals: A Comprehensive Review from 2002-2023](https://mlsanity.com/paper/2309.12202/) (2023)
- [Insights into Schizophrenia: Leveraging Machine Learning for Early Identification via EEG, ERP, and Demographic Attributes](https://mlsanity.com/paper/2503.07650/) (2025)
- [ChatImage: Navigating Long-Form LLM Answers through Interactive Images](https://mlsanity.com/paper/2607.05290/) (2026)

## Abstract (arXiv)

We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently for fMRI, and the proposed architectures essentially focused on a single type of connectivity measure. We propose a deep convolutional neural network (CNN) framework for classification of electroencephalogram (EEG)-derived brain connectome in schizophrenia (SZ). To capture complementary aspects of disrupted connectivity in SZ, we explore combination of various connectivity features consisting of time and frequency-domain metrics of effective connectivity based on vector autoregressive model and partial directed coherence, and complex network measures of network topology. We design a novel multi-domain connectome CNN (MDC-CNN) based on a parallel ensemble of 1D and 2D CNNs to integrate the features from various domains and dimensions using different fusion strategies. Hierarchical latent representations learned by the multiple convolutional layers from EEG connectivity reveal apparent group differences between SZ and healthy controls (HC). Results on a large resting-state EEG dataset show that the proposed CNNs significantly outperform traditional support vector machine classifiers. The MDC-CNN with combined connectivity features further improves performance over single-domain CNNs using individual features, achieving remarkable accuracy of 93.06% with a decision-level fusion. The proposed MDC-CNN by integrating information from diverse brain connectivity descriptors is able to accurately discriminate SZ from HC. The new framework is potentially useful for developing diagnostic tools for SZ and other disorders.