# Deep Neural Networks Improve Radiologists' Performance in Breast Cancer Screening

arXiv: https://arxiv.org/abs/1903.08297 · HTML: https://mlsanity.com/paper/1903.08297/

## Key facts

- Cited by 95 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 20 Mar 2019.

## Built on by (most cited first, 30 of 95)

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- [Act Like a Radiologist: Towards Reliable Multi-view Correspondence Reasoning for Mammogram Mass Detection](https://mlsanity.com/paper/2105.10160/) (2021)
- [Memory-aware curriculum federated learning for breast cancer classification](https://mlsanity.com/paper/2107.02504/) (2021)
- [Superficial White Matter Analysis: An Efficient Point-cloud-based Deep Learning Framework with Supervised Contrastive Learning for Consistent Tractography Parcellation across Populations and dMRI Acquisitions](https://mlsanity.com/paper/2207.08975/) (2022)
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- [A novel multi-view deep learning approach for BI-RADS and density assessment of mammograms](https://mlsanity.com/paper/2112.04490/) (2021)
- [Stabilizing Adversarially Learned One-Class Novelty Detection Using Pseudo Anomalies](https://mlsanity.com/paper/2203.13716/) (2022)
- [Breast Cancer Diagnosis in Two-View Mammography Using End-to-End Trained EfficientNet-Based Convolutional Network](https://mlsanity.com/paper/2110.01606/) (2021)
- [Pretrained ViTs Yield Versatile Representations For Medical Images](https://mlsanity.com/paper/2303.07034/) (2023)
- [Transformers Improve Breast Cancer Diagnosis from Unregistered Multi-View Mammograms](https://mlsanity.com/paper/2206.10096/) (2022)
- [Knowledge Distillation to Ensemble Global and Interpretable Prototype-Based Mammogram Classification Models](https://mlsanity.com/paper/2209.12420/) (2022)
- [Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions](https://mlsanity.com/paper/2304.06662/) (2023)
- [Domain generalization in deep learning-based mass detection in mammography: A large-scale multi-center study](https://mlsanity.com/paper/2201.11620/) (2022)
- [Towards Robust Natural-Looking Mammography Lesion Synthesis on Ipsilateral Dual-Views Breast Cancer Analysis](https://mlsanity.com/paper/2309.03506/) (2023)
- [Multimodal Data Integration for Precision Oncology: Challenges and Future Directions](https://mlsanity.com/paper/2406.19611/) (2024)
- [Cross-Field Transformer for Diabetic Retinopathy Grading on Two-field Fundus Images](https://mlsanity.com/paper/2211.14552/) (2022)
- [Mammo-CLIP: Leveraging Contrastive Language-Image Pre-training (CLIP) for Enhanced Breast Cancer Diagnosis with Multi-view Mammography](https://mlsanity.com/paper/2404.15946/) (2024)
- [Systematic comparison of semi-supervised and self-supervised learning for medical image classification](https://mlsanity.com/paper/2307.08919/) (2023)
- [Delving into Ipsilateral Mammogram Assessment under Multi-View Network](https://mlsanity.com/paper/2309.02197/) (2023)
- [Meta-Learning with Graph Neural Networks: Methods and Applications](https://mlsanity.com/paper/2103.00137/) (2021)
- [Attack-agnostic Adversarial Detection on Medical Data Using Explainable Machine Learning](https://mlsanity.com/paper/2105.01959/) (2021)

## Abstract (arXiv)

We present a deep convolutional neural network for breast cancer screening exam classification, trained and evaluated on over 200,000 exams (over 1,000,000 images). Our network achieves an AUC of 0.895 in predicting whether there is a cancer in the breast, when tested on the screening population. We attribute the high accuracy of our model to a two-stage training procedure, which allows us to use a very high-capacity patch-level network to learn from pixel-level labels alongside a network learning from macroscopic breast-level labels. To validate our model, we conducted a reader study with 14 readers, each reading 720 screening mammogram exams, and find our model to be as accurate as experienced radiologists when presented with the same data. Finally, we show that a hybrid model, averaging probability of malignancy predicted by a radiologist with a prediction of our neural network, is more accurate than either of the two separately. To better understand our results, we conduct a thorough analysis of our network's performance on different subpopulations of the screening population, model design, training procedure, errors, and properties of its internal representations.